Objective：To investigate the efficacy of honeysuckle oral liquid combined with oseltamivir in the treatment of hand-foot-mouth disease （HFMD） in children and its effect on inflammatory factors and immune function. Methods：A total of 86 children with HFMD were randomly divided into control group and experimental group，with 43 cases in each group. The control group was treated with oseltamivir，and the experimental group was treated with honeysuckle oral liquid combined with oseltamivir. Both groups were treated continuously for 7 days. The efficacy and adverse reactions of the two groups were observed. The symptom improvement time of the two groups was recorded. The serum inflammatory factors tumor necrosis factor-α（ TNF-α），interleukin-6（ IL-6） and immune function indexes immunoglobulin （IgM），IgA，IgG were compared between the two groups before and after treatment. Results：The total effective rate of treatment in the experimental group was 90.70 %，which was significantly higher than 74.42% in the control group （P<0.05）. After treatment，compared with the control group，the disappearance time of fever，rash and oral ulcer in the experimental group were significantly shortened （P<0.05）. After treatment，the levels of serum IgM，IgA and IgG in the experimental group were significantly increased（P<0.05）.，and the levels of serum TNF-α and IL-6 were significantly decreased （P<0.05）. There was no significant difference in the incidence of adverse reactions between the two groups （P>0.05）. Conclusion：Jinyinhua Oral Liquid combined with oseltamivir is effective in the treatment of HFMD in children，which can effectively promote symptom relief，improve immune function and reduce inflammation.