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26 December 2022, Volume 12 Issue 6 Previous Issue   

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Action Mechanism of Chemokine Action in Ischemic Stroke Based on GEO Database ZHOU Shu-yang, FU Xu-yang, SUN Yao, WU Wei, ZHAO Shu-ran, LIU Shuo, SHI Rui-li, HAO Xiao-qiong 2022, 12 (6):  1-7.  DOI: 10.3969/j.issn.2095-1396.2022.06.001 Abstract ( 95 )   PDF (9201KB) ( 31 )   Objective：Bioinformatics was used to analyze the mechanism of action in the treatment of ischemic stroke （IS）. Methods：Potential targets for the treatment of IS were identified through the GEO database，signaling pathways，biological processes，and molecular functions involving targets were identified using Gene Ontology （GO） enrichment analysis and Kyoto Gene and Genome Encyclopedia （KEGG） signaling pathway enrichment analysis，protein interaction analysis （PPI） networks were constructed through STRING online databases，imported into Cytoscape software，and built networks，and key targets were screened by CytoHubba plugins. Results：The key targets were identified as C-X-C motif chemokine 8（CXCL8），Tumor necrosis factor（ TNF），and C-X-C motif chemokine 2（CXCL2），interleukin-6（ IL-6），C-X-C motif chemokine 1（ CXCL1），interleukin-1β（ IL-1β），C-C motif chemokine 4（ CCL4），interleukin-1α （IL-1α），Intercellular adhesion molecule 1（ICAM1），Prostaglandin G/H synthase 2（PTGS2），the key pathway is chemokine signaling pathway. Conclusion：The selected key genes may become markers for the diagnosis of IS or potential therapeutic targets，and provide a new theoretical basis for the study of the pathogenesis of the disease. Related Articles | Metrics

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Meta-Analysis of the Clinical Efficacy of Edaravone in the Treatment of Ischaemic Stroke WANG Li-fei, LI Shu-rui 2022, 12 (6):  8-15.  DOI: 10.3969/j.issn.2095-1396.2022.06.002 Abstract ( 67 )   PDF (2225KB) ( 46 )   Objective：To systematically evaluate the therapeutic effect of Edaravone on ischemic stroke. Methods：A computer search was conducted in Cochrane Library，Pubmed， Embase，ClinicalTrials，China knowledge Network database，Wanfang database and VIP periodical resource database. The years were set for each database to be built until December 2022. The literatures about randomized controlled trials and clinical trials of Edaravone in the treatment of ischemic stroke were selected，and the Cochrane risk assessment form was used to evaluate the quality of the retrieved literature. The experimental data related to research were extracted by Revman5.4 software and analyzed by Meta. Results：A total of 28 clinical trials were included. Meta-analysis showed that NIHSS score ［MD=-3.85，95% CI（-4.94，-2.77）］ and ADL score ［MD=13.37，95%CI（11.05，15.69）］ in the treatment of ischemic stroke with Edaravone. The improvement of related indexes was better than that of conventional treatment. Conclusion： The clinical efficacy of Edaravone in the treatment of ischemic stroke is better than that of conventional treatment，but high-quality clinical studies are still needed for further evidence. Related Articles | Metrics

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Systematic Review and Meta - Analysis of Different Administration Modes of Ambroxol Hydrochloride in the Treatment of Respiratory Diseases ZHAO Yong, TANG Tao 2022, 12 (6):  16-24.  DOI: 10.3969/j.issn.2095-1396.2022.06.003 Abstract ( 112 )   PDF (1841KB) ( 84 )   Objective：To systematically evaluate two different drug delivery methods of nebulized inhalation and intravenous drip administration of amiloride hydrochloride （hereinafter referred to as nebulized administration and drip administration） for the treatment of different respiratory system diseases. Methods：PubMed，Web of Science，China Journal Full Text Database （CNKI），Chinese Science and Technology Journal Full Text Database （VIP） and Wanfang Database were systematically searched for all published articles on different administration modes of Ambroxol hydrochloride for the treatment of respiratory diseases at home and abroad， and the quality of relevant included literature was evaluated. Meta - analysis was performed using Stata 16.0 and 14.0 data statistical software. Results：A total of 15 relevant studies were included. A total of 1 366 experimental participants were included，of which 683 were administered by intravenous drip and 683 by nebulized inhalation. According to the current domestic research evidence，nebulized inhalation and intravenous drip administration of amiloride hydrochloride have different effects on the adjuvant treatment of respiratory tract infections，and the final results of Meta showed that nebulized administration was more effective than drip administration in the treatment of related respiratory infections，with a log OR=0.87，95% CI（ 0.28，1.46）. In a subgroup analysis，nebulized administration was more effective in curing chronic bronchitis compared to drip administration，with an log OR=1.76，95% CI（ 0.92，2.1）. Meta - analysis showed that nebulized administration of Ambroxol hydrochloride was more effective in treating pediatric respiratory disease than drip administration，log OR=1.12，95% CI（0.67，1.97）. Meta - statistics on the adverse effects of both showed that among the different modes of administration of Ambroxol hydrochloride for different diseases，drip administration was more likely to cause adverse effects such as nausea and allergy，while nebulized administration was less likely to cause adverse effects. The log OR= - 1.38，95% CI （ - 2.221， - 0.54） P=0.00. Conclusion：In clinical treatment，the therapeutic effect of nebulized administration of amiloride hydrochloride is more advantageous than that of conventional drip administration. It is expected to be the preferred choice for the treatment of respiratory diseases. In the clinical treatment process，it is recommended to consider the type of disease to give the drug，and from the consideration of the efficacy and safety in the process of drug use，it is recommended to choose the nebulized inhalation mode of administration of Ambroxol hydrochloride. Related Articles | Metrics

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Clinical Observation on the Treatment of Hypertension with Banxia Baizhu Tianma Tang and Wendan Tang XU Shu - chun, ZHANG Fan 2022, 12 (6):  25-29.  DOI: 10.3969/j.issn.2095-1396.2022.06.004 Abstract ( 96 )   PDF (2176KB) ( 66 )   Objective：To explore the clinical efficacy of Banxia Baizhu Tianma Tang combined with Wendan Tang in treating hypertensive patients. Methods：150 patients with hypertension of phlegm dampness accumulation type admitted from May 2020 to May 2022 were randomly divided into a control group and a study group with 75 cases each. The control group was treated with telmisartan combined with benazepril hydro chlorothiazide，and the study group was treated with Banxia Baizhu Tianma Decoction and Wendan Decoction for 8 weeks. After one course of treatment，observe the clinical efficacy，traditional Chinese medicine syndrome scores， blood pressure levels，and incidence of adverse reactions of the two groups of patients. Results： After 8 weeks of treatment，the clinical efficacy of the study group patients was better than that of the control group （P<0.05），with lower levels of systolic and diastolic blood pressure，SDS and HAMA scores than the control group （P<0.05）. The incidence of adverse reactions such as headache，dizziness，chest tightness，vomiting，phlegm and saliva，poor appetite，insomnia， palpitations，and smooth pulse were lower than the control group （P<0.05），and the incidence the incidence of adverse reactions such as low blood potassium，dizziness，fatigue，headache，and abdominal distension was lower than the control group（ P<0.05）. Conclusion：The clinical efficacy of Banxia Baizhu Tianma Tang combined with Wendan Tang in treating hypertensive patients is significant， which can stabilize blood pressure levels，alleviate negative emotions in patients，and improve their quality of life. It is worth promoting. Related Articles | Metrics

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Effect of Dexmedetomidine Combined with Sufentanil and Dezocine PCIA on Sleep Quality in Patients Undergoing Laparoscopic Total Hysterectomy DAI Qing-ling 2022, 12 (6):  30-34.  DOI: 10.3969/j.issn.2095-1396.2022.06.005 Abstract ( 44 )   PDF (1177KB) ( 28 )   Objective：To investigate the effect of dexmedetomidine combined with sufentanil and dezocine patient-controlled intravenous analgesia （PCIA） on sleep quality in patients undergoing laparoscopic hysterectomy. Methods：80 patients undergoing laparoscopic total hysterectomy in our hospital from January 2020 to December 2022 were randomly divided into control group （n=40） and observation group （n=40）. PCIA was performed in both groups after operation，and continuous analgesia was performed for 48 hours. The observation group was given dexmedetomidine 5 μg·kg-1+dezocine 0.3 mg·kg-1+sufentanil 1.5 μg·kg-1+granisetron 3 mg，and the control group was given dezocine 0.3 mg·kg-1+sufentanil 1.5 μg·kg-1 + granisetron 3 mg. The visual analogue scale （VAS） score，effective pressing times，actual pressing times，remedial analgesia rate and adverse reactions of the two groups were recorded. The pittsburgh sleep quality index （PSQI） and athens insomnia scale （AIS） were assessed before operation，1 day and 3 days after operation. Results：The VAS score of the observation group was significantly lower comparing with the control group（P<0.05）. Compared with the control group，the effective pressing times and actual pressing times of analgesia pump in the observation group decreased （P<0.05），and the remedial analgesia rate decreased （P<0.05）. The incidence of postoperative nausea and vomiting in the observation group was significantly lower comparing with the control group （P<0.05）. The PSQI score and AIS score of the two groups were significantly higher than those before operation（ P<0.05）. Compared with the control group， the PSQI score and AIS score of the observation group were significantly lower at each time point after operation （P<0.05）. The incidence of postoperative sleep disorders in the observation group was 17.50 %，which was significantly lower than 37.50 % in the control group（P<0.05）. Conclusion：Dexmedetomidine combined with sufentanil and dezocine in PCIA after laparoscopic total hysterectomy can provide good analgesic effect，and improve postoperative sleep quality. Related Articles | Metrics

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Efficacy of Honeysuckle Oral Liquid Combined with Oseltamivir in the Treatment of Hand-foot-mouth Disease in Children and Its Effect on Inflammatory Factors and Immune Function CHEN Bin-feng, LIN Feng 2022, 12 (6):  35-39.  DOI: 10.3969/j.issn.2095-1396.2022.06.006 Abstract ( 86 )   PDF (1165KB) ( 59 )   Objective：To investigate the efficacy of honeysuckle oral liquid combined with oseltamivir in the treatment of hand-foot-mouth disease （HFMD） in children and its effect on inflammatory factors and immune function. Methods：A total of 86 children with HFMD were randomly divided into control group and experimental group，with 43 cases in each group. The control group was treated with oseltamivir，and the experimental group was treated with honeysuckle oral liquid combined with oseltamivir. Both groups were treated continuously for 7 days. The efficacy and adverse reactions of the two groups were observed. The symptom improvement time of the two groups was recorded. The serum inflammatory factors tumor necrosis factor-α（ TNF-α），interleukin-6（ IL-6） and immune function indexes immunoglobulin （IgM），IgA，IgG were compared between the two groups before and after treatment. Results：The total effective rate of treatment in the experimental group was 90.70 %，which was significantly higher than 74.42% in the control group （P<0.05）. After treatment，compared with the control group，the disappearance time of fever，rash and oral ulcer in the experimental group were significantly shortened （P<0.05）. After treatment，the levels of serum IgM，IgA and IgG in the experimental group were significantly increased（P<0.05）.，and the levels of serum TNF-α and IL-6 were significantly decreased （P<0.05）. There was no significant difference in the incidence of adverse reactions between the two groups （P>0.05）. Conclusion：Jinyinhua Oral Liquid combined with oseltamivir is effective in the treatment of HFMD in children，which can effectively promote symptom relief，improve immune function and reduce inflammation. Related Articles | Metrics

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Research Progress in Prevention and Treatment of Diabetes Peripheral Neuropathy with Traditional Chinese Medicine YANG Qi, WANG Shun-jie, QIU Zi-wei, DING Yu-feng, CHEN Xiao-wen 2022, 12 (6):  40-44.  DOI: 10.3969/j.issn.2095-1396.2022.06.007 Abstract ( 74 )   PDF (1111KB) ( 62 )   Diabetes peripheral neuropathy belongs to the category of “pulse arthralgia”， “numbness”，“asthenia” and “flaccidity syndrome” in traditional Chinese medicine. Its clinical manifestations are numbness and discomfort of limbs，obvious burning pain，and abnormal sensory activity. In recent years，the incidence rate of DPN has increased year by year，and effective prevention and treatment of DPN has become a hot spot of current research. Traditional Chinese medicine has obvious advantages due to its long history and precise curative effect. In recent years，certain achievements have been made in the prevention and treatment of diabetes peripheral neuropathy with single traditional Chinese medicine and compound Chinese medicine. This paper summarizes the research on the prevention and treatment of diabetes peripheral neuropathy with single traditional Chinese medicine，and reflects on the problems still existing in the current research，in order to better guide the clinical practice and provide ideas for the development and exploration of new Chinese medicine. Related Articles | Metrics

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Research Progress on the Secretion System and Virulence Factors of Pseudomonas Aeruginosa HAN Mei - juan, TANG Jian - hua, LIU Yun - ning 2022, 12 (6):  45-50.  DOI: 10.3969/j.issn.2095-1396.2022.06.008 Abstract ( 88 )   PDF (1172KB) ( 61 )   Pseudomonas aeruginosa，a common gram - negative bacterium in clinical practice，showed inherent or acquired resistance to a variety of antimicrobial agents. Pseudomonas aeruginosa is an important pathogenic mechanism of the secretory system and its virulence factors to promote infection or escape the clearance of the host immune system. It is of great significance to study the pathogenesis of virulence factors in Pseudomonas aeruginosa secretion system for prevention and treatment of infection caused by them. Related Articles | Metrics

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Gene Therapy for Alzheimer’s Disease SI Wen-ying, HOU Yu-qing, SUN Xiao-jing, MENG Xian-yong, DONG Xiao-hua 2022, 12 (6):  51-56.  Abstract ( 43 )   PDF (1159KB) ( 36 )   Alzheimer’s disease （AD），is the most common neurodegenerative disease in older adults with learning，memory，and cognitive dysfunction. Amyloid β-protein deposition and neurofibrillary tangles formed by Tau protein hyperphosphorylation are the most common pathological features in the brain of AD patients. Current drugs used to treat AD are primarily used to relieve symptoms and do not cure the disease. In recent years，with the in-depth study of AD，gene therapy has attracted attention. In this paper，the AD gene therapy targets and gene therapy vectors are introduced，and the future application research prospects are prospected. Related Articles | Metrics

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Research Progress on Potential Therapeutic Targets of Ulcerative Colitis FAN Rong - zhen, GUO Bao, JING Yong - shuai, ZHANG Dan - shen 2022, 12 (6):  57-64.  Abstract ( 63 )   PDF (1226KB) ( 72 )   Ulcerative colitis is a chronic inflammatory bowel disease，and its pathogenesis has not been fully clarified，which is mainly caused by genetic susceptibility，environmental factors，abnormal immune response，microorganisms and other risk factors. Ulcerative colitis is mainly treated by anti - inflammatory and immunosuppression，but there are some problems such as inevitable side effects，high recurrence rate，strong drug resistance and high price. The active ingredients of natural drugs have the characteristics of multi - target，high curative effect and little side effect，and have become an important research object in the treatment of ulcerative colitis. This article reviews the pharmacological action and mechanism of natural active ingredients in the treatment of ulcerative colitis in recent years，hoping to put forward more targeted ideas or strategies for the treatment of ulcerative colitis and provide theoretical basis for the research and development of new drugs. Related Articles | Metrics