ACTA NEUROPHARMACOLOGICA ›› 2020, Vol. 10 ›› Issue (1): 47-53.DOI: 10.3969/j.issn.2095-1396.2020.01.010

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Research Advances in Sarcopenia

HE Pan,LIU Yue-tao,DU Guan-hua,QIN Xue-mei   

  1. 1.  Modern Research Center for Traditional Chinese Medicine,Shanxi University,Taiyuan,030006,China
    2.  Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing,100050,China
  • Online:2020-02-26 Published:2020-02-26
  • Contact: 秦雪梅,女,教授,博士生导师;研究方向:中药药理与新药研发;Tel: +86-0351-7018379,E-mail: qinxm@sxu.edu.cn 杜冠华,男,教授,博士生导师;研究方向:新药研发及神经药理学;E-mail: dugh@imm.ac.cn
  • About author:何盼,女,博士研究生;研究方向:中药药理;E-mail:yxhepan@163.com
  • Supported by:
    山西省研究生教育创新项目(No.2020BY010)

Abstract:

Sarcopenia is an age-related,progressive syndrome,which is characterized by decline of skeletal muscle mass,strength and muscle function. It has high morbidity and complex pathogenesis. Then it leads to the loss of life ability and the decline in life quality of the aged. It is significant to diagnose,prevent and treat sarcopenia early in clinic and practice. In this review,etiology and pathological mechanism of sarcopenia,present treatment and models of the disease are summarized systematically,which could provide a reference for exploring its machenism deeply and screening drugs of the prevention and treatment of sarcopenia.

Key words: sarcopenia, pathogenesis, treatment, model of disease, aging