Neurotoxicity and Prevention of Local Anesthetics in Central Nervous System

doi:10.3969/j.issn.2095-1396.2018.03.003

Abstract

Abstract:

Local anesthetics （LAs） are widely used for caudal，epidural and spinal anesthesia. These drugs manage acute and chronic pain rapidly，however，they are markedly cytotoxic，especially in central nervous system and cardiovascular system. The toxic effects of LAs are dependent on time/dose and usually varies from each other. Recently，many researches focus on the neurotoxicity of LAs. Therefore，we reviewed the neurotoxicity of LAs and prevention of their neurotoxicity.

Key words: local anesthetics, neurotoxicity, neurons, astrocytes, treatments of neurotoxicity

CLC Number:

R964

XING Yuan，ZHANG Nan，ZHANG Wei，REN Lei-ming. Neurotoxicity and Prevention of Local Anesthetics in Central Nervous System[J]. Acta Neuropharmacologica, DOI: 10.3969/j.issn.2095-1396.2018.03.003.

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