Progress on Adipokines Participating in Alzheimer’s Disease

doi:10.3969/j.issn.2095-1396.2017.01.006

Abstract

Abstract: Alzheimer’s disease（AD），also called senile dementia，is one of the most common central neurodegenerative disease in the elderly. And its main pathological changes include the senile plaques formed by β-amyloid protein deposition out of the neuron， neurofibrillary tangles caused by the hyperphosphorylated tau protein in the neuron，and neurons in large number of loss and damage. Recently，the study has showed that Adipokine has closed relationship between β-amyloid protein deposition，hyperphosphorylated tau protein and neuronal apoptosis. This paper is mainly about the effect and mechanism of Adipokine，such as adiponectin，leptin，interleukin-6 and so on，on AD，which aims to provide a new ideas for the clinical treatment of AD.

Key words: Alzheimer&, rsquo, s disease, adipokine, adiponectin, leptin, interleukin-6

CLC Number:

R964

LUO Piao，CHU Shi-feng，CHEN Nai-hong. Progress on Adipokines Participating in Alzheimer’s Disease[J]. Acta Neuropharmacologica, 2017, 7(1): 45-52.

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