Nicotinic Acetylcholine Receptors and Diseases

doi:10.3969/j.issn.2095-1396.2017.01.007

Abstract

Abstract: Nicotine acetylcholine receptors （nAChRs） belong to the ligand gated ion channels，which are expressed not only in nervous systems，but also in non-nervous system.The different subunit composition forms decide the different affinity of agonist and antagonist. In fact，nAChRs have been found not only to perform their classic function at neuromuscular junctions，but also to function in the regulation of numerous central nervous system，such as voluntary movement，memory，addiction，etc. In addition，nAChR is related to pathogenesis，diagnosis，and treatment of neuralgia，Parkinson’s，Alzheimer’s disease，small cell lung cancer，breast cancer，cervical cancer and other diseases. The paper review the correlation of a variety of diseases and nAChRs structure，function，and expounds nAChRs mediated the α-CTx antitumor research progress，in order to provide theoretical basis for research and development of cone snails toxin antitumor drugs.

Key words: nicotine acetylcholine receptor, disease, &, alpha, -conotoxin

CLC Number:

R730

SUN Zhi-hua, LUO Su-lan. Nicotinic Acetylcholine Receptors and Diseases[J]. ACTA NEUROPHARMACOLOGICA, 2017, 7(1): 53-64.

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