Polymeric Micelles for Drug Delivery

Abstract

Abstract: Polymeric micelles are composed by copolymers, which are amphiphilic or oppositely charged in the aqueous solution. The hydrophobic and hydrophilic blocks form core and shell structure of the polymeric micelles. The hydrophilic shell and nanoscale particle size (10-100nm) of the polymeric micelles not only escape recognizing and up taking by the reticuloendothelial system (RES), but also passively target cancer and inflammatory tissue by enhanced permeability and retention effect (EPR). Polymeric micelles are the carrier of anti-cancer, anti-inflammatory and gene therapy medicine. In this review, we summarized the progress of the polymeric micelles, including the classification of the polymeric micelles, micelles preparation, characteristics, drug release and the application of the polymeric micelles.

Key words: nanoscale, polymeric micelles, drug carrier

CLC Number:

R944.9

ZONG Rui, SHEN Li-xia. Polymeric Micelles for Drug Delivery[J]. Acta Neuropharmacologica, 2015, 5(6): 21-29.

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