Acta Neuropharmacologica ›› 2015, Vol. 5 ›› Issue (6): 30-34.

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Application of Natural Antioxidants in the Progress of Alzheimer's Disease

WANG Ying-ying 1,2, SONG Xiu-yun 1, WANG Qi 2, CHEN Nai-hong 1   

  1. 1. State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica &Neuroscience Center, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
    2. Guangzhou University of Chinese Medicine, Institute of Clinical Pharmacology, Guangzhou, 510000, China
  • Online:2015-12-26 Published:2016-03-03
  • Contact: 陈乃宏,男,博士后,研究员;研究方向:神经药理学和神经分子生物学; Tel: +86-010-63165177,E-mail: chennh@imm.ac.cn
  • About author:王莹莹,女,硕士研究生; E-mail:wangyingyingwangye@163.com
  • Supported by:

    国家自然科学基金项目(NO.81173578, 81273629, 81373997, 21272278);北京市自然科学基金项目(NO.7131013、7142115)新药作用机制研究与药效评价北京市重点实验室资助项目(BZ0150)

Abstract: Oxidative stress could easily trigger intracellular signal transduction, catalyze neuronal degeneration, lead to neuronal death and loss, thereby cause and aggravate Alzheimer's disease (AD). Oxidative stress plays a crucial role in the occurrence and development of AD. Active antioxidant actions could prevent, delay, and treatment AD. In various antioxidant interventions, natural antioxidants became focus on field of future anti-AD research and development for their easily ingest, side effects and other characteristics. In this paper, the progress of natural antioxidants in AD prevention and treatment was summarized in recent years.

Key words: Alzheimer's disease, oxidative stress, natural antioxidants, research progress

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