A Review of Studies on Blood Brain Barrier in vitro Model

doi:10.3969/j.issn.2095-1396.2016.01.004

Abstract

Abstract: Blood brain barrier（BBB） is a dynamic physiological structure，which is composed of brain microvascular endothelial cells，astrocytes and pericytes，playing an important role in maintaining homeostasis in the central nervous system. In vitro experiment is the preferred alternative to the study of early central nervous system drugs screening，pathological and physiological mechanism because of high-throughput，efficient，sensitive，rapid，and accurate characteristics. This paper focuses on the types，compositions and application of in vitro models of BBB，reviews the domestic and foreign literatures，describes the classical models and introduces the latest advanced technology，provides a reference for central nervous system drugs screening and in vitro BBB mechanism research.

Key words: blood brain barrier（ BBB）, in vitro model, research progress

CLC Number:

R965.1

QIN Xue-qing，YANG Zhi-hong，SUN Xiao-bo. A Review of Studies on Blood Brain Barrier in vitro Model[J]. Acta Neuropharmacologica, 2016, 6(1): 25-34.

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