芍药苷神经保护作用机制的研究进展

摘要/Abstract

摘要： 芍药苷（paeoniflorin，PF）是芍药的主要有效成分，具有多种药理作用。本文从调节自噬、调节免疫、抑制炎症因子产生、调节钙离子、钾离子通道、阻断酸敏感离子通道、调节MAPK、PI3K/Akt、Nrf2/ARE信号转导通路、对抗神经毒性、激活2型大麻素受体、抗氧化应激、抑制神经细胞凋亡等方面综述芍药苷的神经保护作用。

关键词: PF, 神经保护作用, 氧化应激, 细胞凋亡, 自噬, 炎症因子

Abstract: Paeoniflorin (paeoniflorin, PF) is one of the main effective components of herbaceouspeony with many kinds of pharmacologic effect. This article reviews the neuroprotective effect of paeoniflorin in the following several aspects: regulate autophagy, regulate immunity, inhibit inflammatory cytokines, adjust Ca2+, K+ channels, block acid-sensing ion channels, adjust MAPK、PI3K/Akt、Nrf2/ARE signal pathways, against neurotoxicity, activate cannabinoid receptor 2, antioxidant stress, inhibit neuron cells apoptosis.

Key words: paeoniflorin, neuroprotective effect, oxidant stress, apoptosis, autophagy, inflammatory cytokines

中图分类号:

R965

胡宝玲, 郭春燕. 芍药苷神经保护作用机制的研究进展[J]. 神经药理学报, 2015, 5(6): 51-56.

HU Bao-ling, GUO Chun-yan. Advances Achievements about Neuroprotective Mechanisms of Paeoniflorin[J]. ACTA NEUROPHARMACOLOGICA, 2015, 5(6): 51-56.

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