神经药理学报

神经药理学报 ›› 2024, Vol. 14 ›› Issue (4): 29-.DOI: 10.3969/j.issn.2095-1396.2024.04.005

• 研究论文 • 上一篇    下一篇

益肾补肝健骨方联合依降钙素治疗对原发性骨质疏松症的疗效及对骨代谢及氧化应激影响

戴秀霞，林海洋，苏子镇，邱英杰，苏丽云，陈丽凤   

  1. 1. 厦门市中医院推拿三科，厦门，361100，中国 

    2. 陆军第七十三集团军医院中医科，厦门，361100，中国 

    3. 宁化县中医院康复科，三明，365499，中国 

    4. 厦门市中医院中医特色诊疗部，厦门，361100，中国

  • 出版日期:2024-08-26 发布日期:2025-01-04
  • 通讯作者: 陈丽凤，硕士研究生，副主任医师；研究方向：中医内病外治方向；E-mail：cliFENG32@126.com
  • 作者简介:戴秀霞，本科，副主任医师；研究方向：推拿整脊结合运气思维（六气针、司天方、子午流注）治疗脊源性相关性疾病；E-mail：DXIUxia56@163.com
  • 基金资助:
    全国名老中医药专家传承工作室建设项目，厦门市扶持中医药发展专项中医药服务项目（No.XWZY-2023-0503）

To Observe the Effect of Yishen-Buganjiangu Decoction Combined with Ecalcitonin in the Treatment of Primary Osteoporosis and Its Influence on Bone Metabolism and Oxidative Stress

DAI Xiu-xia，LIN Hai-yang，SU Zi-zhen，QIU Ying-jie，SU Li-yun，CHEN Li-feng   

  1. 1. Third Department of Tuina Therapy, Xiamen Hospital of Traditional Chinese Medicine, Xiamen, 361100, China 

    2. Department of Traditional Chinese Medicine, 73rd Group Army Hospital, Xiamen, 361100, China 

    3. Department of Rehabilitation, Ninghua Hospital of Traditional Chinese Medicine, Sanming, 365499, China 

    4. Department of TCM Diagnosis and Treatment, Xiamen Hospital of Traditional Chinese Medicine, Xiamen, 361100, China

  • Online:2024-08-26 Published:2025-01-04

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摘要：

目的：探讨益肾补肝健骨方联合依降钙素治疗对原发性骨质疏松症的疗效及对骨代谢及氧化应激的 影响。方法：80 例骨质疏松患者分为对照组与观察组，对照组肌内注射依降钙素，10 IU·次-1，2 次·周-1 ；观察组 在对照组基础上加益肾补肝健骨方治疗，两组均治疗6 个月。比较两组疗效和治疗前后骨密度、骨痛情况[ 视 觉模拟评分（visual analogue scale, VAS）]、骨代谢指标[ Ⅰ型前胶原氨基端前肽（procollagen type Ⅰ N-terminal propeptide, PINP）及Ⅰ型胶原交联C- 末端肽（type I C-terminal cross linked peptide, CTX-1）] 和血清氧化应激指 标[ 丙二醛（malondialdehyde, MDA）及高级氧化蛋白产物（advanced oxidation protein product, AOPP）]。结果： 治疗后，观察组总有效率更高（97.50% vs 82.50%，P<0.05），VAS 评分更低（P<0.05）。治疗后，两组PINP 均上升 （P<0.05），且观察组更高（P<0.05）；两组CTX-1 均下降（P<0.05），且观察组更低（P<0.05）。两组不良反应发生率 差异不具有统计学意义（P>0.05）。结论：益肾补肝健骨方辅助西药治疗原发性骨质疏松症疗效显著，可改善患者 骨代谢及氧化应激情况。

关键词: 原发性骨质疏松, 依降钙素, 益肾补肝健骨方, 骨代谢, 氧化应激

Abstract:

Objective： To investigate the effect of Yishen-Buganjiangu decoction combined with ecalcitonin on primary osteoporosis and its influence on bone metabolism and oxidative stress. Methods: Eighty patients with osteoporosis were divided into a control group and an observation group. The control group received intramuscular injection of ecalcitonin, 10 IU·time-1, twice a week. The observation group was treated with Yishen Bugan Jiangu decoction on the basis of the control group. Both groups were treated for 6 months. The curative effect, bone mineral density, bone pain [visual analogue scale (VAS)], bone metabolism index [procollagen type Ⅰ N-terminal propeptide (PINP), type I C-terminal cross linked peptide (CTX-1), serum oxidative stress markers [malondialdehyde (MDA) and advanced oxidation protein product (AOPP)]before and after treatment were compared between the two groups. Results: After treatment, the total effective rate of the observation group was higher than that of the control group (97.50% vs 82.50%, P<0.05), and the VAS score was lower than that of the control group (P<0.05). After treatment, PINP increased in the two groups (P<0.05), and it was higher in the observation group (P<0.05). The levels of CTX-1 in the two groups were decreased (P<0.05), and the level in the observation group was lower (P<0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P>0.05). Conclusion: Yishen Bugan Jiangu Decoction combined with western medicine is effective in the treatment of primary osteoporosis, which can improve bone metabolism and oxidative stress.

Key words: primary osteoporosis, calcitonin, Yishen Bugan Jiangu decoction, bone metabolism, oxidative stress

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