神经药理学报 ›› 2014, Vol. 4 ›› Issue (3): 39-48.

• 综述 • 上一篇    下一篇

中药对脑缺血再灌注损伤保护作用及机制研究进展

王树林, 安芳   

  1. 河北北方学院,张家口,075000,中国
  • 出版日期:2014-06-26 发布日期:2015-01-20
  • 通讯作者: 安芳,男,教授,硕士,硕士生导师;研究方向:药效学和药动学;联系电话:86-0313-4029558, E-mail:anfang1965@aliyun.com.cn
  • 作者简介:王树林,女,河北北方学院药理学研究生;E-mail:wangshulin1988@126.com

Review of the Effect of Chinese Traditional Medicine on Mechanism of Cerebral Ischemia Reperfusion Injury

WANG Shu-lin, AN Fang   

  1. Hebei North University, Zhangjiakou, 075000, China
  • Online:2014-06-26 Published:2015-01-20
  • Contact: 安芳,男,教授,硕士,硕士生导师;研究方向:药效学和药动学;联系电话:86-0313-4029558, E-mail:anfang1965@aliyun.com.cn
  • About author:王树林,女,河北北方学院药理学研究生;E-mail:wangshulin1988@126.com

摘要: 中药对脑缺血再灌注的保护作用已成为近年来的研究热点,本文将中药按单味中药及其提取物、中药复方和中药注射液进行分类,综述了不同类型的中药对脑缺血再灌注损伤的保护作用机制。中药在对脑缺血再灌注的干预方面具有多层次、多靶点、多环节的作用,文章分别从脑缺血再灌注后的能量代谢障碍、线粒体损伤、自由基损伤、兴奋性氨基酸的毒性作用、炎症损伤、血脑脊液屏障破坏六个方面进行阐述,并对中药的发展进行展望。

关键词: 中药, 脑缺血再灌注损伤, 机制

Abstract: Recent years, the protection of Chinese traditional medicine on Cerebral Ischemia Reperfusion Injury has become the research hotspot. The paper classified Chinese traditional medicine into single herbs and extracts, Chinese traditional medicine and Chinese medicine injection, and summarized the protection mechanism of different Chinese traditional medicine on damage mechanism of Cerebral Ischemia Reperfusion Injury. The interference effects of Chinese traditional medicine on Cerebral Ischemia Reperfusion Injury have multi-level, multi-targeted and multi-link. The article, in several ways including metabolic disorder of energy, mitochondria damage, free radical injury, toxic effect of excitatory amino acid, inflammatory injury and disruption of the blood-brain barrier, summarized the research development and indicated the prospect of Chinese traditional medicine.

Key words: chinese traditional medicine, cerebral ischemia reperfusion injury, mechanisms

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