神经药理学报

神经药理学报 ›› 2023, Vol. 13 ›› Issue (4): 8-.DOI: 10.3969/j.issn.2095-1396.2023.04.002

• 综述 • 上一篇    下一篇

液质联用技术在中药化学成分中的研究进展

尤斯涵，殷宏艳，杨宋蕊，刘家萌，郭春燕   

  1. 河北北方学院药学院，河北省神经药理学重点实验室，张家口，075000，中国
  • 出版日期:2023-08-26 发布日期:2024-05-09
  • 通讯作者: 郭春燕，女，教授，硕士生导师；研究方向：体内药物分析和靶向药物分析；E-mail：guochy0311@163.com
  • 作者简介:尤斯涵，女，研究方向：网络药理学；E-mail:478032008@qq.com

Research Progress of Liquid Chromatography-Mass Spectrometry Technology in the Chemical Composition of Traditional Chinese Medicine

YOU Si-han, YIN Hong-yan, YANG Song-rui, LIU Jia-meng, GUO Chun-yan   

  1. Department of Pharmacy, Hebei North University, Hebei Key Laboratory of Neuropharmacology, Zhangjiakou, 075000, China
  • Online:2023-08-26 Published:2024-05-09
  • Contact: 郭春燕，女，教授，硕士生导师；研究方向：体内药物分析和靶向药物分析；E-mail：guochy0311@163.com
  • About author:尤斯涵，女，研究方向：网络药理学；E-mail:478032008@qq.com

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摘要：

随着液相色谱-质谱（liquid chromatography-mass spectrometry， HPLC-MS）联用技术的发展，其已被广泛用于中药分析中。该技术不仅提供了快速的色谱分离和较短的运行色谱时间，而且具有高灵敏度和选择性，有助于鉴定中药各种化合物的结构、分析中药作用机制。该文对近年来液质联用技术在中药化学成分分析、质量控制以及中药药物代谢动力学方面的研究进展进行综述以期为中药的深入研究和进一步的发展提供新的思路和方法。

关键词: 液质联用技术, 中药化学成分分析, 中药质量控制, 中药药物代谢动力学

Abstract:

With the development of liquid chromatography-mass spectrometry (HPLC-MS), it is widely used in the analysis of traditional Chinese medicine. This technology not only provides fast chromatographic separation and short running chromatographic time, but also has high sensitivity and selectivity, which is helpful to identify the structure of various compounds of traditional Chinese medicine and analyze the mechanism of action of traditional Chinese medicine. This article reviews the research progress of liquid chromatography-mass spectrometry technology in the analysis of chemical components, quality control, and pharmacokinetics of traditional Chinese medicine in recent years, in order to provide new ideas and methods for the in-depth research and further development of traditional Chinese medicine.

Key words: liquid mass spectrometry, analysis of chemical components of traditional Chinese medicine, quality control of traditional Chinese medicine, pharmacokinetics of traditional Chinese Medicine