神经药理学报 ›› 2023, Vol. 13 ›› Issue (4): 29-.DOI: 10.3969/j.issn.2095-1396.2023.04.005

• • 上一篇    下一篇

人类肾脏疾病动物模型研究进展

王倩茹,侯久文,梅其炳   

  1. 1 西南医科大学药学院,泸州,646000,中国 

    2 泸州新药评价研究中心,泸州,646000,中国

  • 出版日期:2023-08-26 发布日期:2024-05-09
  • 通讯作者: 梅其炳,教授,博士生导师;研究方向:分子药理学;E-mail:qbmei@swmu.edu.cn
  • 作者简介:王倩茹,在读硕士研究生;研究方向:分子药理学;E-mail:wqr981020@163.com。侯久文为本文共同第一作者,贡献与第一作者同等

Research Progress on Animal Models of Human Kidney Disease

WANG Qian-ru, HOU Jiu-wen, MEI Qi-bing   

  1. 1. College of Pharmacy, Southwest Medical University, Luzhou, 646000, China 

    2. Luzhou New drug Evaluation Research Center, Luzhou, 646000, China

  • Online:2023-08-26 Published:2024-05-09
  • Contact: 梅其炳,教授,博士生导师;研究方向:分子药理学;E-mail:qbmei@swmu.edu.cn
  • About author:王倩茹,在读硕士研究生;研究方向:分子药理学;E-mail:wqr981020@163.com。侯久文为本文共同第一作者,贡献与第一作者同等

摘要:

肾脏疾病严重威胁人们健康,构建与人类肾脏疾病更加相近的动物模型对深入探讨肾脏疾病的发病机制,以及发现治疗药物具有十分重要意义。该文根据肾脏疾病诱因对动物模型进行分类,分别对糖尿病肾病、肾小球肾炎、高血压肾病、尿酸性肾病、梗阻性肾病、药物肾损伤性及缺血性肾病的实验动物模型及其研究进展进行综述。

关键词: 动物模型, 肾脏疾病, 人类疾病动物模型

Abstract:

Kidney Disease is a serious threat to people's health, so it is very important to replicate the animal model which is more similar to human kidney disease in order to further explore the pathogenesis of Kidney Disease and find therapeutic drugs. In this paper, animal models of diabetic nephropathy, glomerulonephritis, hypertensive nephropathy, uric acid nephropathy, obstructive nephropathy, drug-induced renal injury and ischemic nephropathy were reviewed.

Key words: animal model, kidney disease, animal model of human disease