神经药理学报

神经药理学报 ›› 2022, Vol. 12 ›› Issue (3): 44-.DOI: 10.3969/j.issn.2095-1396.2022.03.009

• 2022年实验动物模型研讨会会议论文 • 上一篇    下一篇

仔猪断奶应激综合征与腹泻型肠易激综合征肝郁脾虚证对比研究

魏媛媛，张艳楠，樊艺萌，尕玉，王惠茹，韩俊成，吕建雨，郝智慧   

  1. 1. 中国农业大学动物医学院，中兽医药创新中心，北京，100193，中国  2. 中华人民共和国农业农村部，中兽医生物学重点实验室，北京，100193，中国  3. 新疆农业大学动物医学院，乌鲁木齐，830000，中国
  • 出版日期:2022-06-26 发布日期:2022-06-26
  • 通讯作者: 郝智慧，博士，教授，博士生导师；研究方向：主要从事中兽医药创新及机理研究；E-mail：haozhihui@cau.edu.cn
  • 作者简介:魏媛媛，博士；研究方向：主要从事中兽药药理相关研究；E-mail：vyyhebeia@163.com
  • 基金资助:
    国家自然科学基金面上项目（No.32172897），中央本级重大增减支项目（名贵中药资源可持续利用能力建设项目（No.2060302））

Comparative Study on Piglet Weaning Stress Syndrome and Diarrhea Type Irritable Bowel Syndrome with Liver Stagnation and Spleen Deficiency Syndrome

WEI Yuan-yuan，ZHANG Yan-nan，FAN Yi-meng，GA Yu，WANG Hui-ru，HAN Jun-cheng， LV Jian-yu，HAO Zhi-hui   

  1. 1.　 China Agricultural University，School of Animal Medicine，Chinese Veterinary Medicine Innovation Center， Beijing，100193，China  2.　 Key Biology Laboratory of Chinese Veterinary Medicine，Ministry of Agriculture and Rural Affairs，Beijing， 100193，China  3.　 Xinjiang Agricultural University，College of Animal Medicine，Wulumuqi，830000，China
  • Online:2022-06-26 Published:2022-06-26

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摘要：

仔猪断奶后1~2 周，通常发生食欲差、消化功能紊乱、腹泻、生长缓慢、饲料利用率低、精神状况以及外 貌表现不佳等一系列变化的现象，总称仔猪断奶应激综合征。其病死率较高，即使耐受也会严重影响到仔猪后期 生长发育和成年后的生产性能，临床治愈率不高，并缺乏合适的实验动物模型用以研究。经文献分析，仔猪断奶 应激综合征和腹泻型肠易激综合征肝郁脾虚证在病因、病机和证型上有共同之处。因此该文就仔猪断奶应激和 腹泻型肠易激综合征动物模型的病因、病机、证型和相关实验动物模型做一综述，为应用腹泻型肠易激综合征肝 郁脾虚证动物模型研究临床复杂性疾病仔猪断奶应激综合征提供支持。

关键词: 仔猪断奶应激, 病证结合, 实验动物模型, 中兽医辨证

Abstract:

One or two weeks after weaning，piglets usually have a series of changes，such as poor appetite，digestive dysfunction，diarrhea，slow growth，low feed utilization rate，poor mental status and poor appearance，which is generally called piglet weaning stress syndrome. Its fatality rate is high，even if it has been tolerated，it will seriously affect the growth and development of piglets in the later stage and the production performance of adults. The clinical cure rate is not high，and there is a lack of suitable experimental animal models for research. According to syndrome differentiation analysis，both piglet weaning stress syndrome and diarrhea irritable bowel syndrome belong to the syndrome of liver depression and spleen deficiency. Therefore，this paper reviews the etiology，pathogenesis，syndrome types and related experimental animal models of weaning stress and diarrhea irritable bowel syndrome in piglets. To provide a reasonable way to study piglet weaning stress syndrome by using the animal model of diarrhea irritable bowel syndrome with liver depression and spleen deficiency syndrome.

Key words: weaning stress of piglets, combination of disease and syndrome, experimental animal model, chinese veterinary syndrome differentiation

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