神经药理学报

神经药理学报 ›› 2021, Vol. 11 ›› Issue (3): 5-9.DOI: 10.3969/j.issn.2095-1396.2021.03.002

• 研究论文 • 上一篇    下一篇

咪达唑仑导致神经功能损伤及作用机制研究

杨蓉，孙振琴，谢文娟，等   

  1. 甘肃省武威肿瘤医院麻醉科，武威，733000，中国
  • 出版日期:2021-06-26 发布日期:2021-06-26
  • 作者简介:杨蓉，女，主治医师；研究方向：麻醉学；E-mail：739172037@qq.com

Study on Nerve Function Injury Induced by Dazolam and Its Mechanism

YANG Rong，SUN Zhen-qin，XIE Wen-juan，NIE Bin，SUN Fu-bang   

  1. Department of Anesthesiology，Wuwei Cancer Hospital of Gansu Province，Wuwei，733000，China
  • Online:2021-06-26 Published:2021-06-26

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摘要：

目的：探讨镇静药咪达唑仑导致神经功能损伤及其机制。方法：将72 只大鼠分为生理盐水对照组、咪达唑仑组、右美托咪定组三个组别，每组各24 只，比较三组大鼠的神经元特异性烯醇化酶（neuron-specific enolase，NSE）、中枢神经特异性蛋白（central nervous specific protein，S100β）、细胞死亡受体Fas 水平、逃逸潜伏期、游泳速度、穿过原平台次数，对NSE、S100β、Fas 病理切片进行分析。结果：与对照组和右美托咪定组相比，咪达唑仑组 NSE、S100β、Fas 水平较高，逃逸潜伏期较长，穿过原平台次较少（P<0.05）。结论：咪达唑仑对神经功能损伤以及学习记忆功能影响较大。

关键词: 镇静药, 咪达唑仑, 右美托咪定, 神经功能损伤

Abstract:

Objective：To investigate the neurologic impairment induced by sedative midazolam and its mechanism. Methods：72 rats were divided into normal saline control group，midazolam group，dexmedetomidine group，each group contained 24 rats. Neuron specificity enolization enzyme（NSE），central nervous specificity protein （S100β），cell death receptor level of Fas，escape latency，swimming speed，through the original number were compaied in three groups. The pathological sections of NSE，S100β and Fas were analyzed. Results：In midazolam group，the levels of NSE，S100β and Fas were higher，the escape latency was longer，and the number of passing through the original platform was less（P<0.05）. Conclusion：Midazolam has a significant effect on neurological impairment and learning and memory functions.

Key words: sedative, midazolam, dexmedetomidine, neurological impairment

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