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26 December 2023, Volume 13 Issue 6 Previous Issue   

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Efficacy of Mouse Nerve Growth Factor Combined with rt-PA in the Treatment of Acute Cerebral Infarction and Its Effect on Serum ET-1 and TXA2 Levels ZHANG Jin-yuan, LIANG Hua-min, MA Wei 2023, 13 (6):  1.  DOI: 10.3969/j.issn.2095-1396.2023.06.001 Abstract ( 13 )   PDF (1024KB) ( 3 )   Objective：To investigate the clinical effect of mouse nerve growth factor （mNGF） combined with alteplase （rt-PA） in patients with acute cerebral infarction （ACI）. Methods： A total of 80 ACI patients were randomly divided into control group （40 cases） and observation group （40 cases）. The control group was treated with rt-PA thrombolytic therapy， and the observation group was treated with mNGF on the basis of rt-PA thrombolytic therapy. Both groups were treated for 14 days. Before and after treatment， the National Institutes of Health Stroke Scale （NIHSS） was used to evaluate the neurological function of the patients， the Barthel Index （BI） was used to evaluate the daily living ability of the patients， and the serum C-reactive protein （CRP）， erythrocyte sedimentation rate （ESR） and endothelin-1 （ET-1） and thromboxane A2 （TXA2） were detected. The differences in indicators and adverse reactions between the two groups were compared， and the incidence of adverse reactions in the two groups was counted. Results： Compared the total effective rate of the two groups， the observation group （95.00 %） was higher than the control group （80.00 %） ， and the difference was significant （P <0.05）. After treatment，compared with the control group， the NIHSS score was lower and the BI score was higher in the observation group （P <0.05）. The levels of serum CRP，ESR， ET-1 and TXA2 in the observation group were also significantly decreased （P <0.05）. There was no significant difference in the incidence of adverse reactions between the two groups （P >0.05）. Conclusion： mNGF combined with rt-PA in the treatment of ACI can improve the curative effect， promote the recovery of neurological function， and reduce the levels of serum ET-1 and TXA2. Related Articles | Metrics

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Study on the Analgesic Effect of Resveratrol in the Context of Pharmacognosy CHEN Yan-ming, CHEN Jin-song 2023, 13 (6):  6.  DOI: 10.3969/j.issn.2095-1396.2023.06.002 Abstract ( 13 )   PDF (1335KB) ( 3 )   Objective: The food and medicine industry is an integral part of the national strategy to develop a “healthy China”. Resveratrol is a naturally occurring compound that has been shown to be biologically active in various diseases such as inflammation, heart disease and cancer. The aim of this study was to investigate the analgesic effects of resveratrol in acute and chronic pain in mice. Methods: In this study, the analgesic effects of resveratrol were evaluated by constructing mouse models of acute pain (acetic acid-induced torsion, formalin-induced persistent pain) and chronic pain (paclitaxel-induced neuropathic pain). Results: The behavioural results showed that resveratrol was effective in reducing acute and chronic pain behaviour in mice and exhibited beneficial effects. Conclusion: Therefore, resveratrol may be a potential drug for the treatment of acute and chronic pain in mice. This study provides a certain theoretical basis for subsequent related studies and offers new ideas and methods for safe and effective clinical analgesia. Related Articles | Metrics

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Analysis of the Effect of Yigui Yufeng Decoction Combined with Acupuncture on the Curative Effect and Inflammatory Factor Level of Ischemic Strok ZHAO Han-qing, FENG Peng-chao, ZHOU Li-fei, LI Li 2023, 13 (6):  12.  DOI: 10.3969/j.issn.2095-1396.2023.06.003 Abstract ( 8 )   PDF (1001KB) ( 3 )   Objective： To investigate the clinical efficacy of Yigui Yufeng Decoction in patients with ischemic stroke and its effect on the level of inflammatory factors. Methods： 82 patients with ischemic stroke were randomly divided into treatment group and control group， 41 cases in each group. The control group was treated with conventional western medicine， and the treatment group was treated with Yigui Yufeng Decoction and acupuncture on the basis of the control group. The treatment time of the two groups was 14 days. The effective rate of treatment and the levels of serum high-sensitivity C-reactive protein （hs-CRP）， blood homocysteine （Hcy） and D-dimer before and after treatment were compared between the two groups. The activities of daily living scale （ADL score） and NIHSS scale score were compared between the two groups before and after intervention. Results： After 14 days of treatment， the effective rate of the treatment group was （ 92.68 %）， and that of the control group was （ 73.17 %）. The difference was statistically significant（ P <0.05）. After treatment， the levels of the above factors in the treatment group were lower than those in the control group （P <0.05）. After treatment， the ADL score of the treatment group was higher than that of the control group， and the NIHSS score was lower than that of the control group （P <0.05）. Conclusion： Yigui Yufeng Decoction combined with acupuncture has a good therapeutic effect on patients with ischemic stroke. It can significantly improve the clinical symptoms of patients， reduce the level of inflammatory factors in the body， and improve the quality of life and neurological function of patients. Related Articles | Metrics

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Regulation Mechanism of Xijiao Dihuang Decoction on Coagulation Function in Septic Rats LIANG Zhi-qi, SHAO Dan, CHEN Hong-jie, LI An-qi, WU Hui 2023, 13 (6):  16.  DOI: 10.3969/j.issn.2095-1396.2023.06.004 Abstract ( 7 )   PDF (966KB) ( 2 )   Objective：To investigate the regulatory mechanism of Xijiao Dihuang decoction on coagulation function in septic rats. Methods： Ninety rats were randomly divided into treatment group， model group and sham operation group， with 30 rats in each group. The sepsis model was established by cecal ligation and puncture in the treatment group and the model group， and the cecum was gently turned without ligation and puncture in the sham-operation group. After successful modeling， the treatment group was given Xijiao Dihuang decoction by gavage， and the model group and sham operation group were given normal saline by gavage for 3 consecutive days. Plasma tissue factor（ TF）， antithrombin-III（ AT-Ⅲ）， activated protein C（ APC）， tissue factor pathway inhibitor （TFPI） and plasminogen activator inhibitor-1 （PAI-1） levels were detected by ELISA AT 24， 48 and 72 hours after gavage in the treatment group， model group and sham operation group. Results： There was no significant difference in TF， AT-Ⅲ， APC， TFPI and PAI-1 between the sham operation group and the control group AT 24， 48 and 72 h （P>0.05）. Compared with the sham operation group， TF， TFPI and PAI-1 in the model group increased and AT-Ⅲ and APC decreased AT 24， 48 and 72 h， and the differences were statistically significant （P<0.05）. In the model group， TF， AT-Ⅲ， APC， TFPI and PAI-1 showed progressive changes with time AT 24， 48 and 72 h， and the differences were statistically significant （P<0.05）. Compared with the model group， TF and PAI-1 in the treatment group decreased， while AT-Ⅲ， APC and TFPI increased AT 24， 48 and 72 h， and the differences were statistically significant （P<0.05）. The levels of TF， AT-Ⅲ， APC， TFPI and PAI-1 in the treatment group AT 24， 48 and 72 h showed progressive changes with time， and the differences were statistically significant （P<0.05）. Conclusion： The mechanism by which Xijiao Dihuang Decoction regulates coagulation function is related to the decrease of TF and PAI-1 and the increase of AT-Ⅲ， APC， and TFPI in septic rats， but further exploration is needed. Related Articles | Metrics

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Efficacy and Safety of Tirofiban Combined with Thromboaspiration in Percutaneous Coronary Intervention Surgery： A Meta-Analysis YANG Bo, ZHAO Xiao-min, LU Meng, ZHANG Ze-peng, WU Chang-sha, LI Fang-jiang 2023, 13 (6):  21.  DOI: 10.3969/j.issn.2095-1396.2023.06.005 Abstract ( 27 )   PDF (1814KB) ( 16 )   Objective：To analyze the efficacy and safety of thrombus aspiration combined with intracoronary injection of tirofiban during percutaneous coronary intervention （PCI）. Methods： PubMed， Embase， Cochrane Library， CNKI， Wanfang Database， Weipu Database （VIP）， and China Biomedical Literature Database were searched in computer from the establishment of the library to the publication of the literature in November 2022. Quality was assessed by two investigators and statistically analyzed using Revman 5.3 software. Results： A total of 7 randomized controlled trials with a total of 1 152 patients were included， including 585 in the combination therapy group and 567 in the PCI alone group. Among them， 708 were males and 444 were females. According to the results of meta-analysis， the ST segment drop in patients treated with acute myocardial infarction （AMI） in the combination group was greater than 50% （RR=1.23， 95%CI 1.14~1.33， P<0.01）， postoperative TIMI grade 3 blood flow （RR=1.20， 95%CI 1.14~1.27，P<0.01）， left ventricular ejection fraction（ LVEF）（ MD=3.32， 95%CI 1.51~5.13，P<0.01）， left ventricular end diastolic diameter（ LVEDD）（ MD=-2.22， 95%CI -4.17~-0.28，P<0.05）， creatine kinase isoenzyme（ CKMB） peak （MD=-111.85， 95%CI -116.43~-107.27， P<0.01） were better than PCI alone， and the incidence of major adverse cardiovascular events （MACE） in the combination therapy group （RR=0.54， 95%CI 0.38~0.75， P<0.01） was lower than PCI alone. Conclusion： The efficacy and safety of the combination therapy group were better than those in the PCI alone group. Related Articles | Metrics

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Study on the Effect and Neurohumoral Effect of Minimally Invasive Gastritis Resection Combined with Potassium Sodium Hydrogen Citrate in Patients with Giant Gastritis YANG Fu-song, YANG Yang, WANG Zhong-bo, ZENG Ying-Jie, GUO Hang 2023, 13 (6):  31.  DOI: 10.3969/j.issn.2095-1396.2023.06.006 Abstract ( 5 )   PDF (964KB) ( 2 )   Objective：To study the effect of minimally invasive gastritis resection combined with potassium sodium hydrogen citrate in patients with giant gastritis and its influence on neurofluid. Methods： 213 patients with giant gouty stones admitted to the First People's Hospital of Anning City from November 2020 to April 2022 were selected as the study objects. They were randomly divided into study group （n=107） and control group （n=106） by computer numbered odd-even number method. The control group was treated with traditional surgery combined with potassium sodium hydrogen citrate. In the study group，minimally invasive gastritis resection combined with potassium sodium hydrogen citrate was selected. The efficacy， pain degree， joint function， renal function index and neurohumoral factor level were compared between the two groups. Results： The total effective rate of the study group was higher than that of the control group（ 97.19% vs 86.79%）（ P<0.05）. The visual analogue scale（ VAS） scores of both groups were lower than those before surgery， but the Hospital for Special Surgery （HSS） scores were higher than those before surgery. The VAS score of the study group was lower than that of the control group， and the HSS score was higher than that of the control group （all P<0.05）. The levels of renal function indexes in both groups were lower after operation， and the study group was lower than the control group （all P<0.05）. The levels of neurohumoral factors in the two groups were higher than those before surgery， but those in the study group were lower than those in the control group（ all P<0.05）. Conclusion： The effect of minimally invasive gastritis resection combined with potassium sodium hydrogen citrate in the treatment of giant gastritis is better， which can effectively improve the pain degree， joint function， kidney function and neurohumoral factor level of patients. Related Articles | Metrics

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Extraction and Content Determination of Total Volatile Oil in Perilla Leaf Grown in Zhangjiakou LUO Fei, WANG Ying, FENG Ting-ting, HE Wei 2023, 13 (6):  36.  DOI: 10.3969/j.issn.2095-1396.2023.06.007 Abstract ( 11 )   PDF (1149KB) ( 2 )   Objective：The contents of total volatile oil in Perilla leaves sold on the market and those planted in Baicao Garden of Hebei North University were determined by HPLC. The contents of total volatile oil were compared to evaluate whether the Perilla leaves planted in Baicao Garden of our school reached the market standard. Methods： Total volatile oils were extracted from two kinds of Perilla leaves by heating reflux method with 20 times anhydrous ethanol in 85℃ water bath for 1h. The content of Perilla aldehyde in total volatile oil was determined by HPLC， and the content of total volatile oil in two groups of Perilla leaves was calculated. Results： According to the linear regression equation， the content of Perilla aldehyde and total volatile oil in Perilla leaves sold on the market was 0.109% and 1.162%. The content of total volatile oil in Perilla leaves planted in our school was 0.102% and 1.090%. Conclusion： Although the content of volatile oil of Perilla leaves planted in Baicao Garden of our school is slightly lower than that of Perilla leaves sold on the market， it has reached the standard of market sale. Related Articles | Metrics

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Clinical Efficacy of Jianzhong Yuyang Tablet in Treating Gastrointestinal Ulcer Bleeding and Its Influence on Gastroenteric Electroencephalogram DOU Hui-qiang 2023, 13 (6):  40.  DOI: 10.3969/j.issn.2095-1396.2023.06.008 Abstract ( 15 )   PDF (957KB) ( 2 )   Objective：To analyze the clinical efficacy of Jianzhong Yuyang tablet in the treatment of gastrointestinal ulcer bleeding and its influence on gastroenteric electroencephalogram. Methods： A total of 106 patients with gastrointestinal ulcer bleeding treated in our hospital from August 2021 to August 2023 were selected and divided into 2 groups according to different treatment methods. 52 cases in the comparison group were given conventional symptomatic treatment with Western medicine，and 54 cases in the observation group were given Jianzhong Yuyang tablet on the basis of the comparison group. The clinical efficacy，pH value of gastric fluid， hemoglobin （Hb）， electrogastroenterogram and serum inflammatory factors were compared between the two groups. Results： The total clinical effective rate of observation group（ 96.30%） was higher than that of comparison group（ 76.92%）（ P<0.05）. After treatment，the pH and Hb of gastric juice in observation group were higher than those in comparison group （P<0.05）. After treatment， the average amplitude of stomach body， gastric antrum， transverse colon， descending colon and rectum in observation group was higher than that in comparison group （P<0.05）. The levels of hypersensitive C-reactive protein （hs-CRP）， interleukin-10 （IL-10） and IL-8 in the observation group after treatment were lower than those in the control group （P<0.05）. Conclusion： Jianzhong Yuyang Tablet can effectively improve the symptoms of ulcer and bleeding in patients with gastrointestinal ulcer hemorrhage， increase Hb， regulate gastroenteric electroencephalogram， and reduce inflammation. Related Articles | Metrics

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Research Progress of Core Markers and Other Markers of Alzheimer's Disease YIN Hong-yan, YOU Si-han, GUO Chun-yan 2023, 13 (6):  45.  DOI: 10.3969/j.issn.2095-1396.2023.06.009 Abstract ( 10 )   PDF (976KB) ( 5 )   Alzheimer's disease （AD） is a neurodegenerative disease that cannot be cured until now. The main existing diagnostic methods are the detection of biomarkers in cerebrospinal fluid and positron emission tomography （PET）， but their application in clinical practice is hampered due to the invasiveness and high cost of their testing. Biomarkers in blood samples can make early detection and diagnosis of ad universal because of their easy availability and low price. This article summarizes several common biomarkers of AD and their changes in AD patients， and prospects the development of ad biomarkers in the future. Related Articles | Metrics

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Research Status on the Neuroprotective Effect of Probucol ZHU Jing-yi , FAN Jian-chun, YU Ai-mei 2023, 13 (6):  50.  DOI: 10.3969/j.issn.2095-1396.2023.06.010 Abstract ( 16 )   PDF (926KB) ( 6 )   Probucol has two easily oxidized phenolic hydroxyl groups， which can combine with oxygen free radicals to form a stable phenolic oxygen group. It has powerful lipid-lowering， anti-inflammatory and antioxidant functions and plays an important role in the treatment process. This article reviews the protective effects and detailed protective mechanisms of probucol in the central nervous system and peripheral nervous system based on domestic and foreign literature in recent years. Related Articles | Metrics

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Mechanism of Action of Vaccine Adjuvants and Research Progress ZHANG Xin-yan, SHI Xiao-zi, ZHAO Yong-ming 2023, 13 (6):  55.  DOI: 10.3969/j.issn.2095-1396.2023.06.011 Abstract ( 37 )   PDF (961KB) ( 21 )   Vaccination is currently the most economically effective method for preventing infectious diseases. Adjuvants are substances added to vaccines to enhance antigens immunogenicity. The appropriate addition of adjuvants can better assist vaccines in stimulating the body， achieving efficient and long-lasting immune responses， reducing the production costs of vaccines， and minimizing the dosage of drugs， thus decreasing the toxic side effects of drugs entering the human body. This article provides a comprehensive review of commonly used adjuvants and their immunogenic properties. It aims to serve as a reference for the design and selection of safe and effective vaccine adjuvants. Related Articles | Metrics