ACTA NEUROPHARMACOLOGICA

Methods and Evaluation of Animal Models of Induced Bronchial Asthma

ZHANG Dan-shen，ZHANG Nan

2019, 9 (4): 1-8. DOI: 10.3969/j.issn.2095-1396.2019.04.001

Abstract ( 214 )

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Bronchial asthma is a chronic tracheal allergic inflammatory disease in respiratory diseases. Because the cause of asthma is very complicated，its pathogenesis is still not fully understood，and many studies need to be carried out through animal models. This paper details the sex，body weight dosage，and methods，ect. of animals in an animal model of induced asthma. Provides basic information for asthma mechanism research and asthma prevention an treatment，and provides assistance for further research on asthma.

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Analysis of Medication Rules of Traditional Chinese Medicine for Insomnia

FAN Shuai-ke，FANG Xiao-yan，MIAO Ming-san

2019, 9 (4): 9-14. DOI: 10.3969/j.issn.2095-1396.2019.04.002

Abstract ( 219 )

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To analyze the medication rules of Chinese patent medicine for insomnia and tranquilization，and provide the reference for guiding clinical medication and developing new prescriptions. Methods：Using the Chinese patent medicines for insomnia and tranquilization，included in the Ministry of Traditional Chinese Medicine Standards and Chinese Pharmacopoeia 2015 edition as data sources，and Excel 2013 and SPSS Modeler 14.1 as tools，the Chinese medicines included in the standards were statistically processed and analyzed by association rules. Results：Among the prescriptions included in the standard，the top five herbs with the highest cumulative frequency were licorice （26 times，28.57%），astragalus （24 times，26.37%），schisandra （23 times，25.27%），spina date seed （21 times，23.08%） and rehmannia （21 times，23.08%）. Among the medicines，sweet（ 20 times，45.45%），bitter（ 11 times，25%），acid（ 5 times，11.36%） is the most common，pungent （4 times，9.10%），salty （2 times，4.54%），astringent（1 time，2.27%），light（ 1 time，2.27%） and so on. The drug properties were mainly concentrated in cold（ 8 times，30.77%） and mild（ 9 times，34.62%） levels（ 8 times，30.77%）. The central meridian（13 times，19.12%），liver meridian （13 times，19.12%），kidney meridian （13 times，19.12%），lung meridian （11 times，16.18%） and spleen meridian （9 times，13.24%） are the most common. As can be seen from the distribution of dosage forms，there are various kinds of Chinese patent medicine dosage forms for treating insomnia and tranquilizing the mind.

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