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Research Progress of Cortical Spreading Depression ZHAO Bo, YU Ai-mei, ZOU Yu-an ACTA NEUROPHARMACOLOGICA    2022, 12 (3): 28-.   DOI: 10.3969/j.issn.2095-1396.2022.03.006 Abstract （512）      PDF（pc） （1210KB）（141）       Knowledge map    Save Cortical spreading depression is an inhibitory band of electrical activity generated after the cerebral cortex is stimulated. This inhibitory band can rapidly destroy and depolarize the concentration gradient of transmembrane ions in the cerebral cortex，resulting in short circuits inside and outside cells，which can affect brain perfusion and metabolism.resulting in a poor prognosis. This paper will summarize the research progress of CSR from the following aspects. Related Articles | Metrics | Comments（0）

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Evaluation of APP/PS-1/Tau Female Mice to Simulate the Pathological Model of Female AD DU Jia-rui, LIU Fu-wang, SHEN Xu-ri, et al ACTA NEUROPHARMACOLOGICA    2022, 12 (5): 1-.   DOI: 10.3969/j.issn.2095-1396.2022.05.001 Abstract （145）      PDF（pc） （16584KB）（69）       Knowledge map    Save Objective：To screen an animal model that is compatible with female AD syndrome and to provide a basis for the study of compound therapeutic targets for AD. Methods： 3×Tg-AD female mice as the research object and C57BL/6J （wild type，WT） female mice as the control，the estrogen level in vivo was detected by Elisa. Differences in femoral bone mass and ovarian aging were observed by HE staining. The spatial learning and memory of mice were measured by Morris water maze. Immunofluorescence staining was used to detect the expression of APP/PS-1/Tau protein in the hippocampus. Nissl staining was used to observe the neuronal Nissl bodies in the brain. Results：The estrogen，bone mass of femur and ovary of female mice at the age of 3，6 and 10 months were significantly down-regulated in an age-dependent manner.Morris water maze data showed that the escape latency of 3×Tg-AD mice at the age of 6 and 10 months was significantly higher than WT mice. Immunofluorescence staining showed that the co-expression of Aβ/PS-1/Tau protein increased in the hippocampus of 3×Tg-AD mice at 10 months of age. Compared with the control group，the neurons in the hippocampus of 3×Tg-AD mice aged 3-month-old were neatly arranged，with clear cell layers and larger cell bodies，with no significant difference. While neurons in 6-month-old 3×Tg-AD mice were loosely arranged， Nissl body dissolved and disappeared，with the number decreased，and the arrangement and apoptosis of neurons in 10-month-old mice were more obvious. Conclusion：The 10-month-old 3×Tg-AD mice had learning and memory impairment，increased Aβ accumulation and Tau in the brain，significantly decreased estrogen levels in vivo，significant differences in femoral bone mass and significant signs of ovarian apoptosis.it coincides with the clinicopathological symptoms of postmenopausal women with AD，which is an ideal female dementia model. Related Articles | Metrics | Comments（0）

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Research Progress of Inflammatory Related Derivative Indices and Acute Myocardial Infarction WANG Jia-qi, WU Lu-lu, ZHANG Fei-fei, GAO Man, DANG Yi, QI Xiao-yong ACTA NEUROPHARMACOLOGICA    2022, 12 (3): 11-.   DOI: 10.3969/j.issn.2095-1396.2022.03.003 Abstract （144）      PDF（pc） （1215KB）（37）       Knowledge map    Save Acute myocardial infarction （AMI） is the most serious type of cardiovascular disease，which can lead to arrhythmia，heart failure and even sudden death. Recent studies have shown that inflammatory response is closely related to the occurrence and development of AMI and the damage repair after myocardial infarction. As an important part of human immune system，various inflammatory cells are involved in the occurrence and development of AMI. Inflammation-related derived indicators such as NLR，LMR and SII can reflect the inflammatory state of the body，and a large number of studies have found that they have certain predictive value in the diagnosis，treatment，prognosis and complications of AMI. This article mainly reviews the role of inflammation-related derived indicators in AMI，in order to provide a new basis for the pathogenesis and treatment of AMI. Related Articles | Metrics | Comments（0）

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The Regulatory Mechanism of Protein S-Nitrosylation and Its Relationship with Nervous System Diseases HUA Dan, ZHOU Xue-xia, WANG Qian, SHI Cui-juan, TANG Li-da, YU Shi-zhu ACTA NEUROPHARMACOLOGICA    2022, 12 (3): 17-.   DOI: 10.3969/j.issn.2095-1396.2022.03.004 Abstract （144）      PDF（pc） （1311KB）（34）       Knowledge map    Save Protein S-nitrosylation refers to the process of attaching a nitric oxide （NO）-derived group to a cysteine （Cys） thiol to generate S-nitrosothiol （SNO）. S-nitrosylation is a reversible posttranslational modification，which acts a key role in the signal transduction pathway contributing to a variety of physiological and pathological processes in the nervous system. This article will summarize the regulatory mechanism of S-nitrosylation，its relationship with the pathogenesis，and the treatment of neurological diseases based on S-nitrosylation，in order to provide a new idea for the development of such research in the future. Related Articles | Metrics | Comments（0）

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A Preliminary Study on the Effect of 5-HT2A/D2 Receptor Balancing Antagonist NH809 on Schizophrenia YU Min-quan, XU Xiang-qing ACTA NEUROPHARMACOLOGICA    2022, 12 (3): 1-.   DOI: 10.3969/j.issn.2095-1396.2022.03.001 Abstract （114）      PDF（pc） （1284KB）（42）       Knowledge map    Save Objective：To investigate the pharmacological effects of 5-HT2A/D2 receptor balancing antagonist NH809 on schizophrenia in vivo. Methods：The effects of NH809 on schizophrenia in vivo were evaluated by MK-801 hydrogen maleat（0.3 mg·kg-1，ip） induced hyperactivity model in mice，apomorphine （1 mg·kg-1，sc） induced climbing model in mice and conditioned avoidance response（CAR） in rats，and compared with risperidone. Results：NH809 had dose-dependent inhibitory effect on MK-801 hydrogen maleate induced high activity model，apomorphine-induced climbing behavior in mice and conditioned avoidance response in vivo，with ED50 of 0.04，0.05 and 0.24 mg·kg-1，respectively. The ED50 of risperidone in these three models were 0.06，0.68 and 0.60 mg·kg-1，respectively. Conclusion：NH809 has significant pharmacological effects on several animal models of schizophrenia，and its activity in vivo is better than risperidone. Related Articles | Metrics | Comments（0）

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Research Progress on the Application of Accelerated Repetitive Transcranial Magnetic Stimulation CUI Pei, SUN Yu-jiao, CHEN Jing-jing, ZHANG Xin-yu, DONG Yan-hong ACTA NEUROPHARMACOLOGICA    2022, 12 (3): 23-.   DOI: 10.3969/j.issn.2095-1396.2022.03.005 Abstract （108）      PDF（pc） （1189KB）（30）       Knowledge map    Save Repetitive transcranial magnetic stimulation as a non-invasive brain stimulation technique，has been widely used in neuroscience research and the treatment of some neuropsychiatric diseases. Accelerated repetitive transcranial magnetic stimulation will increase the daily use frequency on the basis of conventional transcranial magnetic stimulation. This article will briefly review the intervention study of accelerated transcranial magnetic stimulation on common brain diseases and the comparison with conventional schemes. Related Articles | Metrics | Comments（0）

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Index of the 2022 National Conference on Cognition, Aging and Related Diseases ACTA NEUROPHARMACOLOGICA    2022, 12 (5): 62-.   Abstract （104）      PDF（pc） （751KB）（20）       Knowledge map    Save Related Articles | Metrics | Comments（0）

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3D Clinostat Simulates the Effects of Microgravity on the Bones and Hearts of Mice SONG Chen-chen, XIONG Yi, KANG Tai-sheng, SHI Xu-dong, GAO Kai, DONG Wei, GUO Jian-guo, QIN Chuan ACTA NEUROPHARMACOLOGICA    2022, 12 (3): 39-.   DOI: 10.3969/j.issn.2095-1396.2022.03.008 Abstract （99）      PDF（pc） （2236KB）（38）       Knowledge map    Save Objective：To explore the effect of 3D clinostat simulation microgravity effect on mice bones and heart. Methods：Twenty-five 8-week-old male C57BL/6J mice were randomly divided into 5 groups （n= 3~5）：ground control group （GC group），3-week-treated control group （TC3 group），3 weeks simulated microgravity group （SM3 group），6-week-treated control group （TC6 group），6 weeks simulated microgravity group （SM6 group）. Micro-CT was used to detect the changes of left femur parameters in mice. Results：The results showed that compared with GC group，the bone volume/tissue volume and trabecular thickness of mice in TC3，SM3，TC6 and SM6 groups were significantly decreased （P<0.05），the trabecular spaceing was significantly increased （P<0.05）. There was no significant difference in trabecular number and cortical bone wall thickness. After 3 weeks of treatment with the 3D clinostat，other heart parameters did not change compared to the thinning of the LVPW in mice. Diastolic and systolic left ventricle diameter decreased，LV Mass became lighter，and tight space led to increased stroke volume and ejection fraction. Conclusion：Microgravity effects simulated by 3D clinostat can lead to bone loss in mice，and affect the structure and function of the heart with time effect. Related Articles | Metrics | Comments（0）

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Clinical Observation of Rivaroxaban and Warfarin in the Treatment of Cerebral Venous Sinus Thrombosis LU Fei-hu, YU Xue ACTA NEUROPHARMACOLOGICA    2022, 12 (3): 5-.   DOI: 10.3969/j.issn.2095-1396.2022.03.002 Abstract （95）      PDF（pc） （1231KB）（21）       Knowledge map    Save Objective：To analyze the anticoagulant effect of rivaroxaban and warfarin on cerebral venous sinus thrombosis. Methods：A total of 52 patients with cerebral venous sinus thrombosis admitted to the Third People’s Hospital of Bengbu from February 2018 to February 2022 were selected as the research objects，and were divided into observation group（n=25） and control group （n=27） according to different anticoagulant drugs. The observation group was given rivaroxaban for anticoagulation treatment，and the control group was given warfarin for anticoagulation treatment. The results of international normalized ratio （INR） and activated partial thromboplastin time （APTT） and the occurrence of bleeding and embolism complications during treatment were analyzed and compared between the two groups for 3 months after anticoagulation treatment，so as to study and compare the anticoagulation efficacy of drugs in the treatment of cerebral venous sinus thrombosis between the two groups. Results：The results of INR and APTT were （1.4±0.3） s and （40.1±2.5） s respectively in the observation group after 3 months of anticoagulant treatment，which were lower than those in the control group （2.5±0.7） s and （42.3±4.0） s，the difference was statistically significant （P<0.05）. One case of skin and mucous membrane hemorrhage occurred in the observation group. The incidence of bleeding complications in the observation group was lower than that in the control group，and the difference was statistically significant （P<0.05）. There were one case of ischemic cerebral infarction in the observation group and three cases of ischemic cerebral infarction in the control group，as well as one case of severe pulmonary embolism and one case of deep venous thrombosis of lower limbs. The incidence of venous and arterial embolization adverse events was lower than that of the control group，but the difference was not statistically significant （P>0.05）. Conclusion：The rivaroxaban drugs in the treatment of cerebral venous sinus thrombosis，clinical effect is significantly better than that of warfarin anticoagulant drugs to have a lower incidence of bleeding，the rivaroxaban anticoagulant thrombosis appeared in the process of adverse events and warfarin had no significant differences，these make it on in the treatment of cerebral venous sinus thrombosis in clinical effect is better than drug warfarin. Related Articles | Metrics | Comments（0）

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Safety Risk Management of Pediatric Compound Amino Acid Injection for Children YAN Ming, WU Zhi-ang ACTA NEUROPHARMACOLOGICA    2022, 12 (5): 10-.   DOI: 10.3969/j.issn.2095-1396.2022.05.002 Abstract （91）      PDF（pc） （1515KB）（26）       Knowledge map    Save Objective：Drug safety is not“ zero risk”. Awareness of drug safety is generally limited due to the shortage of sample size，shorter observation time and single subjects in premarket clinical trials，and many potential risks have not been discovered. To analyze drug safety risk management of Pediatric Compound Amino Acid Injection，further improve and optimize the safety risk management measures. Methods：This article summarized and analyzed the monitoring data of adverse reactions of Pediatric Compound Amino Acid Injection from 2016 to 2019，including analysis of medication population，medication reasons，usage and dosage， route of administration and medication area. Identified and evaluated the potential safety risks of the products，implemented the safety control measures of the products，minimized the risks， and effectively guaranteed the medication safety of patients. Results：The adverse reactions of the product mainly focus on unexpected types，and their SOC are mainly focus on skin and subcutaneous tissue disorders and Gastrointestinal disorders. In addition，the fast drip was an important reason for the adverse reactions of Pediatric Compound Amino Acid Injection，and there is also obvious region difference. The major causes include the lack of clinical medication standards，clinical medication habits，inadequate hospital monitoring and management，and cognitive deviation of medical staff. Conclusion：The adverse reactions of skin and subcutaneous tissue disorders and Gastrointestinal disorders are added to product patient inserting，which can guide clinical medication and greatly reduce the risk of new adverse reactions. The analysis results showed that after the training of salesmen and the face to face communication of clinical medical and nursing personnel，the adverse reactions caused by fast drip decreased from 12.67% to 6.47%. The drug safety risk management methods and measures of this product are effective. Related Articles | Metrics | Comments（0）

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Comparative Study on Piglet Weaning Stress Syndrome and Diarrhea Type Irritable Bowel Syndrome with Liver Stagnation and Spleen Deficiency Syndrome WEI Yuan-yuan, ZHANG Yan-nan, FAN Yi-meng, GA Yu, WANG Hui-ru, HAN Jun-cheng, LV Jian-yu, HAO Zhi-hui ACTA NEUROPHARMACOLOGICA    2022, 12 (3): 44-.   DOI: 10.3969/j.issn.2095-1396.2022.03.009 Abstract （83）      PDF（pc） （1197KB）（21）       Knowledge map    Save One or two weeks after weaning，piglets usually have a series of changes，such as poor appetite，digestive dysfunction，diarrhea，slow growth，low feed utilization rate，poor mental status and poor appearance，which is generally called piglet weaning stress syndrome. Its fatality rate is high，even if it has been tolerated，it will seriously affect the growth and development of piglets in the later stage and the production performance of adults. The clinical cure rate is not high，and there is a lack of suitable experimental animal models for research. According to syndrome differentiation analysis，both piglet weaning stress syndrome and diarrhea irritable bowel syndrome belong to the syndrome of liver depression and spleen deficiency. Therefore，this paper reviews the etiology，pathogenesis，syndrome types and related experimental animal models of weaning stress and diarrhea irritable bowel syndrome in piglets. To provide a reasonable way to study piglet weaning stress syndrome by using the animal model of diarrhea irritable bowel syndrome with liver depression and spleen deficiency syndrome. Related Articles | Metrics | Comments（0）

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Protective Effect and Mechanism of Sodium Aescinate on Renal Ischemia Reperfusion ZHAO Peng-tao, YAN Ju-han, YAN Xiao-dong, et al ACTA NEUROPHARMACOLOGICA    2022, 12 (5): 17-.   DOI: 10.3969/j.issn.2095-1396.2022.05.003 Abstract （77）      PDF（pc） （1055KB）（32）       Knowledge map    Save Aescin is a kind of triterpenoid saponin compound extracted from the traditional Chinese medicine sorrel. Aescin sodium has anti-inflammatory，anti-exudation，analgesic，antiviral， regulating energy metabolism，improving vascular tension，etc. It is mostly clinically used in acute lung injury，gastrointestinal protection，improving blood circulation and correcting brain dysfunction，etc. effect. Some domestic studies have found that aescin sodium has a certain protective effect on renal ischemia reperfusion injury （IRI）. The signaling pathway （ROS-AMPKmTOR） regulates mitophagy and reduces oxidative stress，but the specific protective mechanism of aescin sodium on renal IRI still needs to be further explored. Therefore，this article intends to review the protective mechanism of aescin sodium in improving renal IRI. Related Articles | Metrics | Comments（0）

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2022 National Conference on Cognition, Aging and Related Diseases ACTA NEUROPHARMACOLOGICA    2022, 12 (5): 24-.   Abstract （74）      PDF（pc） （2590KB）（44）       Knowledge map    Save Related Articles | Metrics | Comments（0）

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2022 Laboratory Animal Model Symposium Conference Abstract ACTA NEUROPHARMACOLOGICA    2022, 12 (3): 52-.   Abstract （65）      PDF（pc） （1840KB）（19）       Knowledge map    Save Related Articles | Metrics | Comments（0）

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Study on the Prevention and Treatment Mechanism of Single Herb Extract on Acute Lung Injury XU Fei, WU Jiu-zai, ZHANG Qiang-qiang, CHEN Zheng-yuan, CHEN Dong ACTA NEUROPHARMACOLOGICA    2022, 12 (3): 34-.   DOI: 10.3969/j.issn.2095-1396.2022.03.007 Abstract （60）      PDF（pc） （1146KB）（19）       Knowledge map    Save Acute lung injury is a serious respiratory disease，which has high incidence rate and mortality. Western medicine mainly focuses on targeted supportive treatment，but there is no effective treatment way at present. On the contrary，traditional Chinese medicine has the characteristics of multi-target，multi-component，low sideeffects，and has unique advantages in the prevention and treatment of acute lung injury. At the same time，in recent years，with the in-depth study of traditional Chinese medicine on acute lung injury，achieved ideal results. Therefore，this paper reviews the mechanism of single herbextracts in the prevention and treatment of acute lung injury，in order to provide scientific basis for basic experimental research and clinical application in this field. Related Articles | Metrics | Comments（0）

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Action Mechanism of Chemokine Action in Ischemic Stroke Based on GEO Database ZHOU Shu-yang, FU Xu-yang, SUN Yao, WU Wei, ZHAO Shu-ran, LIU Shuo, SHI Rui-li, HAO Xiao-qiong ACTA NEUROPHARMACOLOGICA    2022, 12 (6): 1-7.   DOI: 10.3969/j.issn.2095-1396.2022.06.001 Abstract （53）      PDF（pc） （9201KB）（22）       Knowledge map    Save Objective：Bioinformatics was used to analyze the mechanism of action in the treatment of ischemic stroke （IS）. Methods：Potential targets for the treatment of IS were identified through the GEO database，signaling pathways，biological processes，and molecular functions involving targets were identified using Gene Ontology （GO） enrichment analysis and Kyoto Gene and Genome Encyclopedia （KEGG） signaling pathway enrichment analysis，protein interaction analysis （PPI） networks were constructed through STRING online databases，imported into Cytoscape software，and built networks，and key targets were screened by CytoHubba plugins. Results：The key targets were identified as C-X-C motif chemokine 8（CXCL8），Tumor necrosis factor（ TNF），and C-X-C motif chemokine 2（CXCL2），interleukin-6（ IL-6），C-X-C motif chemokine 1（ CXCL1），interleukin-1β（ IL-1β），C-C motif chemokine 4（ CCL4），interleukin-1α （IL-1α），Intercellular adhesion molecule 1（ICAM1），Prostaglandin G/H synthase 2（PTGS2），the key pathway is chemokine signaling pathway. Conclusion：The selected key genes may become markers for the diagnosis of IS or potential therapeutic targets，and provide a new theoretical basis for the study of the pathogenesis of the disease. Related Articles | Metrics | Comments（0）

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Systematic Review and Meta - Analysis of Different Administration Modes of Ambroxol Hydrochloride in the Treatment of Respiratory Diseases ZHAO Yong, TANG Tao ACTA NEUROPHARMACOLOGICA    2022, 12 (6): 16-24.   DOI: 10.3969/j.issn.2095-1396.2022.06.003 Abstract （53）      PDF（pc） （1841KB）（32）       Knowledge map    Save Objective：To systematically evaluate two different drug delivery methods of nebulized inhalation and intravenous drip administration of amiloride hydrochloride （hereinafter referred to as nebulized administration and drip administration） for the treatment of different respiratory system diseases. Methods：PubMed，Web of Science，China Journal Full Text Database （CNKI），Chinese Science and Technology Journal Full Text Database （VIP） and Wanfang Database were systematically searched for all published articles on different administration modes of Ambroxol hydrochloride for the treatment of respiratory diseases at home and abroad， and the quality of relevant included literature was evaluated. Meta - analysis was performed using Stata 16.0 and 14.0 data statistical software. Results：A total of 15 relevant studies were included. A total of 1 366 experimental participants were included，of which 683 were administered by intravenous drip and 683 by nebulized inhalation. According to the current domestic research evidence，nebulized inhalation and intravenous drip administration of amiloride hydrochloride have different effects on the adjuvant treatment of respiratory tract infections，and the final results of Meta showed that nebulized administration was more effective than drip administration in the treatment of related respiratory infections，with a log OR=0.87，95% CI（ 0.28，1.46）. In a subgroup analysis，nebulized administration was more effective in curing chronic bronchitis compared to drip administration，with an log OR=1.76，95% CI（ 0.92，2.1）. Meta - analysis showed that nebulized administration of Ambroxol hydrochloride was more effective in treating pediatric respiratory disease than drip administration，log OR=1.12，95% CI（0.67，1.97）. Meta - statistics on the adverse effects of both showed that among the different modes of administration of Ambroxol hydrochloride for different diseases，drip administration was more likely to cause adverse effects such as nausea and allergy，while nebulized administration was less likely to cause adverse effects. The log OR= - 1.38，95% CI （ - 2.221， - 0.54） P=0.00. Conclusion：In clinical treatment，the therapeutic effect of nebulized administration of amiloride hydrochloride is more advantageous than that of conventional drip administration. It is expected to be the preferred choice for the treatment of respiratory diseases. In the clinical treatment process，it is recommended to consider the type of disease to give the drug，and from the consideration of the efficacy and safety in the process of drug use，it is recommended to choose the nebulized inhalation mode of administration of Ambroxol hydrochloride. Related Articles | Metrics | Comments（0）

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Efficacy of Honeysuckle Oral Liquid Combined with Oseltamivir in the Treatment of Hand-foot-mouth Disease in Children and Its Effect on Inflammatory Factors and Immune Function CHEN Bin-feng, LIN Feng ACTA NEUROPHARMACOLOGICA    2022, 12 (6): 35-39.   DOI: 10.3969/j.issn.2095-1396.2022.06.006 Abstract （52）      PDF（pc） （1165KB）（16）       Knowledge map    Save Objective：To investigate the efficacy of honeysuckle oral liquid combined with oseltamivir in the treatment of hand-foot-mouth disease （HFMD） in children and its effect on inflammatory factors and immune function. Methods：A total of 86 children with HFMD were randomly divided into control group and experimental group，with 43 cases in each group. The control group was treated with oseltamivir，and the experimental group was treated with honeysuckle oral liquid combined with oseltamivir. Both groups were treated continuously for 7 days. The efficacy and adverse reactions of the two groups were observed. The symptom improvement time of the two groups was recorded. The serum inflammatory factors tumor necrosis factor-α（ TNF-α），interleukin-6（ IL-6） and immune function indexes immunoglobulin （IgM），IgA，IgG were compared between the two groups before and after treatment. Results：The total effective rate of treatment in the experimental group was 90.70 %，which was significantly higher than 74.42% in the control group （P<0.05）. After treatment，compared with the control group，the disappearance time of fever，rash and oral ulcer in the experimental group were significantly shortened （P<0.05）. After treatment，the levels of serum IgM，IgA and IgG in the experimental group were significantly increased（P<0.05）.，and the levels of serum TNF-α and IL-6 were significantly decreased （P<0.05）. There was no significant difference in the incidence of adverse reactions between the two groups （P>0.05）. Conclusion：Jinyinhua Oral Liquid combined with oseltamivir is effective in the treatment of HFMD in children，which can effectively promote symptom relief，improve immune function and reduce inflammation. Related Articles | Metrics | Comments（0）

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Clinical Observation on the Treatment of Hypertension with Banxia Baizhu Tianma Tang and Wendan Tang XU Shu - chun, ZHANG Fan ACTA NEUROPHARMACOLOGICA    2022, 12 (6): 25-29.   DOI: 10.3969/j.issn.2095-1396.2022.06.004 Abstract （45）      PDF（pc） （2176KB）（21）       Knowledge map    Save Objective：To explore the clinical efficacy of Banxia Baizhu Tianma Tang combined with Wendan Tang in treating hypertensive patients. Methods：150 patients with hypertension of phlegm dampness accumulation type admitted from May 2020 to May 2022 were randomly divided into a control group and a study group with 75 cases each. The control group was treated with telmisartan combined with benazepril hydro chlorothiazide，and the study group was treated with Banxia Baizhu Tianma Decoction and Wendan Decoction for 8 weeks. After one course of treatment，observe the clinical efficacy，traditional Chinese medicine syndrome scores， blood pressure levels，and incidence of adverse reactions of the two groups of patients. Results： After 8 weeks of treatment，the clinical efficacy of the study group patients was better than that of the control group （P<0.05），with lower levels of systolic and diastolic blood pressure，SDS and HAMA scores than the control group （P<0.05）. The incidence of adverse reactions such as headache，dizziness，chest tightness，vomiting，phlegm and saliva，poor appetite，insomnia， palpitations，and smooth pulse were lower than the control group （P<0.05），and the incidence the incidence of adverse reactions such as low blood potassium，dizziness，fatigue，headache，and abdominal distension was lower than the control group（ P<0.05）. Conclusion：The clinical efficacy of Banxia Baizhu Tianma Tang combined with Wendan Tang in treating hypertensive patients is significant， which can stabilize blood pressure levels，alleviate negative emotions in patients，and improve their quality of life. It is worth promoting. Related Articles | Metrics | Comments（0）

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2022 Laboratory Animal Model Symposium Conference Abstract Index ACTA NEUROPHARMACOLOGICA    2022, 12 (3): 64-.   Abstract （41）      PDF（pc） （854KB）（14）       Knowledge map    Save Related Articles | Metrics | Comments（0）