Abstract: Low back pain caused by lumbar intervertebral disc herniation （LDH） is closely related to inflammation. Inflammatory factors stimulate nerve fibers may cause pain，which is also one of the reasons for the degeneration of the intervertebral disc. At present，there is a lack of stable and reliable anti-inflammatory drugs for lumbar disc herniation. The inflammatory mechanism and related signal pathways of lumbar disc herniation were reviewed. According to theoretical laboratory research or ongoing clinical trials，steroidal anti-inflammatory drugs，non-steroidal anti-inflammatory drugs，Chinese medicines，growth factors and cytokines were analyzed. A batch of potential anti-inflammatory drugs，hoping to provide reference and reference for the selection of anti-inflammatory drugs and follow-up treatment for LDH clinical treatment.

Key words: lumbar disc herniation, inflammation, anti-inflammatory drugs