Advances in Research Methods of Blood—Brain Barrier Transporters

doi:10.3969/j.issn.2095-1396.2016.03.007

Abstract

Abstract: Blood—brain barrier (BBB) has been acknowledged as junction with dynamic and highly organized feature between brain and blood. It plays an important role in preventing free passage of solutes and protecting the central nervous system (CNS) by isolating it from the periphery. The abnormal function of it may speed up the deterioration of several neurological diseases. Its function abnormality precedes or accelerates the deterioration of some nervous system diseases. The study of transporters of blood brain barrier is intended to provide a theoretical evidence for analyzing the function of BBB, exploring the pathogenesis of nervous system disease and promoting the development of brain targeted drug. In this article, the blood brain barrier transporter classification and function, blood brain barrier model and transporter research methods are summarized to provide references for drug development, improving target activity and drug interaction.

Key words: blood&, mdash, brain barrier, transporter, blood&, mdash, brain barrier model, research methods

CHEN Jian,HOU Hong-wei，LIU Yong，WANG An，HU Qing-yuan. Advances in Research Methods of Blood—Brain Barrier Transporters[J]. Acta Neuropharmacologica, 2016, 6(3): 44-55.

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