Acta Neuropharmacologica ›› 2016, Vol. 6 ›› Issue (3): 44-55.DOI: 10.3969/j.issn.2095-1396.2016.03.007

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Advances in Research Methods of Blood—Brain Barrier Transporters

CHEN Jian ,HOU Hong-wei,LIU Yong,WANG An,HU Qing-yuan   

  1. 1. China National Tobacco Quality Supervision&Test Center,Zhengzhou,45000l,China
    2. Institute of Applied Technology,Hefei Institutes of Physical Science,C. A. S,Hefei,230088,China
    3. University of Science and Technology of China,Hefei,230026,China
  • Online:2016-06-26 Published:2016-05-10
  • About author:陈建,男,博士,研究方向:吸烟与健康及烟碱致瘾性阈值,TEL:0371-67672036,E-mail:jchen0222@aliyun.com
  • Supported by:

    中国烟草总公司科技重点项目《烟碱致瘾性阈值研究》合同号110201402037

Abstract: Blood—brain barrier (BBB) has been acknowledged as junction with dynamic and highly organized feature between brain and blood. It plays an important role in preventing free passage of solutes and protecting the central nervous system (CNS) by isolating it from the periphery. The abnormal function of it may speed up the deterioration of several neurological diseases. Its function abnormality precedes or accelerates the deterioration of some nervous system diseases. The study of transporters of blood brain barrier is intended to provide a theoretical evidence for analyzing the function of BBB, exploring the pathogenesis of nervous system disease and promoting the development of brain targeted drug. In this article, the blood brain barrier transporter classification and function, blood brain barrier model and transporter research methods are summarized to provide references for drug development, improving target activity and drug interaction.

Key words: blood&, mdash, brain barrier, transporter, blood&, mdash, brain barrier model, research methods