ACTA NEUROPHARMACOLOGICA ›› 2016, Vol. 6 ›› Issue (3): 38-43.DOI: 10.3969/j.issn.2095-1396.2016.03.006

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The Progress of Transient Receptor Potential Channels in Metabolic Syndrome

GAO Yuan-yuan,GUO Chun-yan   

  1. Department of Pharmacy,Hebei North University,Zhangjiakou,075000,China
  • Online:2016-06-26 Published:2016-05-10
  • Contact: 郭春燕,女,教授,研究生导师;研究方向:天然药物中活性成分和体内药物分析;E-mail:997890404@qq.com
  • About author:高圆圆,女,药学系 2014级本科生
  • Supported by:

    河北北方学院博士启动基金

Abstract: The transient receptor potential (TRP) channel superfamily is composed of more than 30 nonselective cation channels. TRP channels are grouped into 7 subfamilies. TRP channel subunits contain six hydrophobic stretches and a putative amino and carboxyl terminal pore area on the cytoplasmic side. Various subtypes play an important role in the metabolic syndrome. Protein,fat,carbohydrates-related metabolic disorders can cause a series of disease,such as obesity, hypertension, diabetes, atherosclerosis, bone and mineral disorders, electrolyte disturbances, inflammatory reaction and cancer. This paper reviews the development and the role of TRP channels in the metabolic syndrome.

Key words: transient receptor potential channels, metabolic syndrome, TRPA, TRPC, TRPM, TRPN, TRPP, TRPV