The Progress of Transient Receptor Potential Channels in Metabolic Syndrome

doi:10.3969/j.issn.2095-1396.2016.03.006

Abstract

Abstract: The transient receptor potential （TRP） channel superfamily is composed of more than 30 nonselective cation channels. TRP channels are grouped into 7 subfamilies. TRP channel subunits contain six hydrophobic stretches and a putative amino and carboxyl terminal pore area on the cytoplasmic side. Various subtypes play an important role in the metabolic syndrome. Protein，fat，carbohydrates-related metabolic disorders can cause a series of disease，such as obesity, hypertension, diabetes, atherosclerosis, bone and mineral disorders, electrolyte disturbances, inflammatory reaction and cancer. This paper reviews the development and the role of TRP channels in the metabolic syndrome.

Key words: transient receptor potential channels, metabolic syndrome, TRPA, TRPC, TRPM, TRPN, TRPP, TRPV

GAO Yuan-yuan, GUO Chun-yan. The Progress of Transient Receptor Potential Channels in Metabolic Syndrome[J]. ACTA NEUROPHARMACOLOGICA, 2016, 6(3): 38-43.

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