Advances Achievements about Neuroprotective Mechanisms of Paeoniflorin

Abstract

Abstract: Paeoniflorin (paeoniflorin, PF) is one of the main effective components of herbaceouspeony with many kinds of pharmacologic effect. This article reviews the neuroprotective effect of paeoniflorin in the following several aspects: regulate autophagy, regulate immunity, inhibit inflammatory cytokines, adjust Ca2+, K+ channels, block acid-sensing ion channels, adjust MAPK、PI3K/Akt、Nrf2/ARE signal pathways, against neurotoxicity, activate cannabinoid receptor 2, antioxidant stress, inhibit neuron cells apoptosis.

Key words: paeoniflorin, neuroprotective effect, oxidant stress, apoptosis, autophagy, inflammatory cytokines

CLC Number:

R965

HU Bao-ling, GUO Chun-yan. Advances Achievements about Neuroprotective Mechanisms of Paeoniflorin[J]. ACTA NEUROPHARMACOLOGICA, 2015, 5(6): 51-56.

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