Application of Angiopep-2 Modified Nanoparticles Loaded With Various Drugs in Glioma

Abstract

Abstract: Glioma is a common primary intracranial tumor, the main reason why it is difficult to cure is that the blood-cerebrospinal fluid barrier prevents the drug from crossing into the brain, thus reducing the drug effective concentration. Secondly, the visible tumor has developed to the middle or late period, missing the right treatment time. Angiopep-2 is a ligand of low density lipoprotein receptor related protein. The LRP is highly expressed on the surface of the blood-cerebrospinal fluid barrier and glioma cells. Angiopep-2 can be modified to the surface of nanoparticles loaded with chemotherapeutic agents or imaging agents, which can achieve targeted drug delivery or significantly improve the imaging effect of glioma. This article reviews the application of the nanoparticles modified with Angiopep-2, providing some ideas and methods for the diagnosis and treatment of glioma.

Key words: Angiopep-2, nanoparticles delivery system, nanoparticles imaging system, glioma

CLC Number:

R739.4

SU Xiao-mei, ZHANG Dan-shen. Application of Angiopep-2 Modified Nanoparticles Loaded With Various Drugs in Glioma[J]. Acta Neuropharmacologica, 2015, 5(6): 57-63.

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