Acta Neuropharmacologica

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Research Progress of Aging-Related Ggene Clk1

ZHAO Xue-ping,ZHANG han,DONG Xiao-hua   

  1. Department of Pharmacy,Hebei North University,Hebei Key Laboratory of Neuropharmacology,Zhangjiakou,075000,China
  • Online:2017-12-26 Published:2017-12-01
  • Contact: 董晓华,女,教授,理学博士;研究方向:神经精神药理学;Tel:+86-0313-4029421,E-mail:hbdxh76@163.com
  • About author:赵学萍,女,硕士研究生;研究方向:神经精神药理学;Tel:+86-0313-4029421,E-mail:940048064@qq.com

Abstract:

Clk1,a mitochondrial enzyme involved in coenzyme Q biosynthesis,plays an role in the aging process. It was found that the loss of Clk1/Mclk1 gene could lead to prolonging the life span of nematodes and mice,but the specific mechanism was not clear. In this review,we summarized and discussed the function of Clk1 gene in organism.

Key words: Clk1, aging, longevity

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