Acta Neuropharmacologica ›› 2016, Vol. 6 ›› Issue (5): 45-52.DOI: 10.3969/j.issn.2095-1396.2016.05.007

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Research Progress on Pinocembrin:Potential Therapeutic Applications and Action Mechanisms

Zhang Hai-wei,Zhang Li   

  1. Department of Pharmacy,Hebei North University,Zhangjiakou,07500,China
  • Online:2016-10-26 Published:2017-01-03
  • Contact: 张力,男,教授,硕士生导师;研究方向:神经药理学;Tel:+86-313-4029188,E-mail:hbnulzhang@126.com
  • About author:张海威,男,硕士研究生;研究方向:神经药理学;E-mail:hwzhang1057@163.com
  • Supported by:

    国家自然科学基金项目(No.81274005),河北省研究生创新资助项目(No.CXZZSS2017146)

Abstract: Pinocembrin is a natural flavonoid compound extracted from propolis,ginger plants,wild marjoram,and other plants which have a higher content. In the preclinical studies,it has shown anti-inflammatory,anti-tumor,antioxidant,decrease blood lipids,neuroprotective effects and other pharmacological effects. In recent domestic and foreign studies focused on pinocembrin neuroprotective effects as well as the ability to attenuate reactive oxygen species,protect the blood-brain barrier,modulate mitochondrial function,and regulate apoptosis. Pinocembrin is a potential drug to treat ischemic stroke and other clinical conditions. In this review,we summarize its pharmacokinetics,mechanisms of action and potential therapeutic applications,in order to provide a reference for pinocembrin mechanisms research and therapeutic applications.

Key words: pinocembrin, pharmacokinetics, therapeutic applications, mechanisms of action, research progress