Characterization on Tissue Distribution of Osthol In Vivo in Rats by Trapezoidal Area Method

Acta Neuropharmacologica ›› 2012, Vol. 2 ›› Issue (4): 13-18.

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Characterization on Tissue Distribution of Osthol In Vivo in Rats by Trapezoidal Area Method

ZHENG Li-qing ¹，LIU Jian-hua，ZHANG Dan-shen^1,2，WU Hai-xia¹，XUE Gui-ping¹

1. Department of pharmacology Heibei North University，Zhangjiakou，075029，China
2. Heibei University of Science and Technology，Shijiazhuang，050017，China

3. The first Affiliated Hospital of Hebei North University，Zhangjiakou，075000，China

Online:2012-08-26 Published:2014-06-27
Contact: 张丹参，女，教授，博士生导师； E-mail: zhangds2011@126.com
About author: 郑立卿，女，讲师，博士，研究方向：药代动力学；Tel：+86-0313-8041659，E-mail:lqzheng@126.com
Supported by:
河北省卫生厅医学科学研究重点课题计划（No.20120155），河北省中医药管理局项目(No.2009065)

Abstract

Abstract: Objective: To study the tissue distribution of ostholon rats and to provide bases for clinical applications. Methods: After osthol was administered to rats (30, 120 mg·kg^-1 ;ip), the concentration of osthol in rat tissues after different time was determined by RP-HPLC. Results: Osthol distributed rapidly in the tissues after ip: eight tissues can detect osthol after 5 min. Heart, liver, lung and kidney all reached C_maxin 10 min_. When the dose is increased 4 folds, T_peaks of osthol in tissues had no significant changes, except the concentration and elimination time increased slightly corresponding to the same time-point. Conclusion: Osthol was distributed rapidly and extensively in the rat’s body and may pass through blood-brain-barrier and blood-testis-barrier.

Key words: osthol, RP-HPLC, rats, tissues distibution

CLC Number:

R965

ZHENG Li-qing，LIU Jian-hua，ZHANG Dan-shen，WU Hai-xia，XUE Gui-ping. Characterization on Tissue Distribution of Osthol In Vivo in Rats by Trapezoidal Area Method[J]. Acta Neuropharmacologica, 2012, 2(4): 13-18.

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Characterization on Tissue Distribution of Osthol In Vivo in Rats by Trapezoidal Area Method

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