The Role of MicroRNA in Learning and Memory Dysfunction

Abstract

Abstract: MicroRNAs (miRNAs) are endogenous small RNAs that can silence the gene expression. miRNAs play an important role in neuronal development，differentiation and function. Neurodegenerative diseases and depression are associated with impairment of learning and memory. The deregulation of miRNAs can affect the occurrence and development of these diseases in many ways. This review highlights the effect of miRNAs on synaptic plasticity and diseases，and also discusses the function of miRNAs in learning and memory dysfunction.

Key words: miRNA, synaptic plasticity, learning, memory, nervous system

CLC Number:

R741
R338

CHEHui, YANG Bao-feng, AIJing. The Role of MicroRNA in Learning and Memory Dysfunction[J]. ACTA NEUROPHARMACOLOGICA, 2011, 1(4): 26-32.

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