Abstract: Objective：To prepare the rhubarb colon-specific pellets，and study on the protection of the pellets in ulcerative colitis （UC） rats. Methods：Sodium alginate，pectin and chitosan were used to prepare the pill-core by dropping preparation method. The oxazolone（OXZ） was used to set up UC model. Wistar rats were randomly divided into protection groups（3 dosage groups：200，140，80 mg·kg-1），normal group and model group before the modeling，each group include 6 rats，male and female half. Protection groups were given pellets by gavage 3 days before the modeling for 8 d with rhubarb colon-specific pellets. The rats were executed at d 9 and the colon tissues were harvested through laparotomy. The wet quality of colon tissues was weighed，and the colon injury was observed. The colon wet quality index was calculated and the colon lesions of rats were graded. Results：The colon wet quality index （7.86，6.20，7.29，7.59，6.11，4.65）（ P<0.05） and colon lesions to the naked eye score（ P<0.01） of the 140 mg·kg-1 group have significant difference with model group. The colon tissue pathological damage of the UC rats can be obviously improved with the 140 mg·kg-1 of rhubarb colon-specific pellets. Conclusion：Rhubarb colon-specific pellets have certain protective effect on UC rats.

Key words: rhubarb colon-specific pellets, ulcerative colitis, rat, protection