ACTA NEUROPHARMACOLOGICA ›› 2020, Vol. 10 ›› Issue (3): 8-16.DOI: 10.3969/j.issn.2095-1396.2020.03.002

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Preparation and Pharmacological Activities of Resveratrol Nanoparticles

DU Bao-ze, TAN Xiao-hong   

  1. Department of Pharmacy,Hebei North University,Zhangjiakou,075000,China
  • Online:2020-06-26 Published:2021-05-14
  • Contact: 谭晓虹,女,副教授,研究方向:药物化学
  • About author:都保泽,男,2016 级制药工程专业,现在就职于康龙化成(北京)新药技术股份有限公司

Abstract:

Resveratrol with polyphenolic structure has been proved to be reductive,reduce inflammation and has the effects of cardiovascular protection and cellular inhibitory by correlational studies,and resveratrol can not be directly applied to clinical practice,because of poor water solubility,instability and low bioavailability. It is a kind of antitoxin produced by plant body to resist mould infection. It is commonly found in Chinese medicine and food. If resveratrol nanoparticles were prepared by new technology,the water solubility,stability,bioavailability and clinical value of resveratrol can be improved,and it can have the obvious sustanined-release effect and targeting. It has antioxidant,anti-tumor,anti-inflammatory pharmacological activitie. The paper has reviewed the preparation of resveratrol nanoparticles and their pharmacological effects,in order to provide references for the research and development and clinical application,and it’s good to expand view of resveratrol study.

Key words: resveratrol, nanoparticles, preparation method, pharmacological effect

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