神经药理学报

神经药理学报 ›› 2021, Vol. 11 ›› Issue (4): 58-.DOI: 10.3969/j.issn.2095-1396.2021.04.010

• 综述 • 上一篇    

抗炎药与腰椎间盘突出症研究进展

郏振杰，杨新明，丁棚辉   

  1. 1. 浙江省台州市立医院疼痛科，台州，318000，中国
    2. 河北北方学院附属第一医院骨科，张家口，075000，中国
  • 出版日期:2021-08-26 发布日期:2021-08-26
  • 通讯作者: 杨新明，主任医师，教授，硕士生导师；研究方向：创伤、脊柱外科；E-mail：yxm11200@126.com
  • 作者简介:郏振杰，浙江省台州市立医院疼痛科；研究方向：腰椎间盘突出
  • 基金资助:
    浙江省医药卫生科技计划项目（No.2020393881）

Research Progress on Anti-Inflammatory Drugs and Lumbar Intervertebral Disc Herniation

JIA Zhen-jie，YANG Xin-ming，DING Peng-hui   

  1. 1. Department of Pain，Taizhou Municipal Hospital of Zhejiang Province，Taizhou，318000，China
    2. Department of Orthopedics，The First Affiliated Hospital of Hebei North University，Zhangjiakou，075000，China
  • Online:2021-08-26 Published:2021-08-26

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摘要： 腰椎间盘突出症（lumbar intervertebral disc herniation，LDH）引起的腰背痛与炎症关系密切。炎症因子刺激神经纤维可能导致疼痛，也是导致椎间盘退化的原因之一。目前临床上缺乏针对腰椎间盘突出症稳定可靠的抗炎药物。该文回顾了腰椎间盘突出的炎症机制及相关信号通路，根据理论实验室研究或正在进行的临床试验，分析了甾体类抗炎药、非甾体类抗炎药、中药及生长因子和细胞因子等一批潜在抗炎药物，以期为LDH 临床治疗选择抗炎药物和后续治疗提供借鉴和参考。

关键词: 腰椎间盘突出, 炎症, 抗炎药物

Abstract: Low back pain caused by lumbar intervertebral disc herniation （LDH） is closely related to inflammation. Inflammatory factors stimulate nerve fibers may cause pain，which is also one of the reasons for the degeneration of the intervertebral disc. At present，there is a lack of stable and reliable anti-inflammatory drugs for lumbar disc herniation. The inflammatory mechanism and related signal pathways of lumbar disc herniation were reviewed. According to theoretical laboratory research or ongoing clinical trials，steroidal anti-inflammatory drugs，non-steroidal anti-inflammatory drugs，Chinese medicines，growth factors and cytokines were analyzed. A batch of potential anti-inflammatory drugs，hoping to provide reference and reference for the selection of anti-inflammatory drugs and follow-up treatment for LDH clinical treatment.

Key words: lumbar disc herniation, inflammation, anti-inflammatory drugs

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