中药对中枢神经退行性疾病信号通路影响的研究进展

doi:10.3969/j.issn.2095-1396.2017.03.005

摘要/Abstract

摘要： 随着对中药防治中枢神经系统衰老相关疾病发病机制的深入探讨，发现中药通过信号分子Wnt、β-catenin、TCF/ LEF、磷脂酰肌醇3 激酶（ phosphatidylinositol-3 kinase，PI3K）、蛋白激酶B（ protein kinase B，AKT）、哺乳动物雷帕霉素靶蛋白（mammalian target of rapamycin，mTOR）、核因子-κB（nuclear factor kappa B，NF-κB），细胞色素C（cytochrome，Cyt-C）、B 淋巴细胞瘤-2（B-cell lymphoma-2，Bcl-2）家族蛋白、Caspases 酶等，调节Wnt/β-catenin、PI3K/Akt、线粒体凋亡信号通路，发挥对阿尔茨海默病（Alzheimer’s disease，AD）、帕金森病（Parkinson’s disease，PD）、脑缺血等衰老相关中枢神经系统疾病的防治作用。该文着重从以上三条信号通路，对中药在中枢神经系统退行性疾病的防治现状做一阐述。

关键词: Wnt/&beta, -catenin 信号通路, 线粒体凋亡, PI3K/Akt 信号通路, 阿尔茨海默病, 帕金森病

Abstract: It is found that Chinese medicine play a important role in the prevention and treatment of the central nervous system diseases（AD，PD，cerebral ischemia，etc） by adjusting the key signaling molecule such as Wnt，β-catenin，TCF/LEF，PI3K，AKT，mTOR，NF-κB，Cyt-C，Bcl-2 family，Caspases enzyme，etc，along with in-depth study of the pathogenesis on Chinese medicine used to delay aging and prevent age-related diseases. This article focuses on three signaling pathways （Wnt/β-catenin，PI3K/Akt，mitochondrial apoptosis） and reviews the prevention and treatment of Chinese medicine on the central nervous system degenerative diseases mainly.

Key words: Wnt/&beta, -catenin signaling pathway, mitochondrial apoptosis, PI3K/Akt signaling pathway, Alzheimer&rsquo, s disease（ AD）, Parkinson&rsquo, s disease（ PD）

中图分类号:

R285，R964

张丽娜，张欣，薛娟，张丹参. 中药对中枢神经退行性疾病信号通路影响的研究进展[J]. 神经药理学报, 2017, 7(3): 33-42.

ZHANG Li-na，ZHANG Xin，XUE Juan，ZHANG Dan-shen. Advances Achievements of Traditional Chinese Medicine on the Signaling Pathways in Central Nervous Degenerative Diseases[J]. Acta Neuropharmacologica, 2017, 7(3): 33-42.

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