神经药理学报

神经药理学报 ›› 2021, Vol. 11 ›› Issue (6): 53-.DOI: 10.3969/j.issn.2095-1396.2021.06.009

• 综述 • 上一篇    下一篇

PI3K-AKT 信号通路在胃癌中的作用机制及研究进展

郝艳娇，李志宇，常明智，等   

  1. 河北北方学院，基础医学院，张家口，075000，中国
  • 出版日期:2021-12-26 发布日期:2021-12-26
  • 通讯作者: 张晓丽，硕士，教授；研究方向：肿瘤分子病理；E-mail：894915208@qq.com
  • 作者简介:郝艳娇，在读硕士研究生；研究方向：肿瘤分子病理研究；E-mail：j1779719403@163.com

The Mechanism and Research Progress of PI3K-AKT Signaling Pathway in Gastric Cancer

HAO Yan-jiao，LI Zhi-yu，CHANG Ming-zhi，et al   

  1. College of Basic Medicine，Hebei North University，Zhangjiakou，075000，China
  • Online:2021-12-26 Published:2021-12-26

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摘要：

胃癌的发生和发展是一个多步骤、多因素的复杂过程，主要涉及DNA 突变、遗传因素的改变、多种细胞信号传导的异常变化。磷脂酰肌醇3- 蛋白激酶（phosphatidylinositol 3-protein kinase，PI3K）/ 蛋白激酶B（protein kinase B，AKT）信号通路参与肿瘤细胞的恶性进程，该通路紊乱可引起多种疾病。近年来，由于对肿瘤分子基础的深入研究，发现该通路的激活与胃癌细胞的增殖、侵袭、转移、凋亡、血管生成紧密相关。目前，靶向该信号通路已经成为抗肿瘤研究的新趋势，该文就PI3K/AKT 信号通路与胃癌研究进展综述。

关键词: PI3K/AKT 信号通路, 胃癌, 凋亡, 抑制剂

Abstract:

The occurrence and development of gastric cancer is a multi-step and multi factor complex process，which mainly involves DNA mutation，changes of genetic factors and abnormal changes of various cell signal transduction. Phosphatidylinositol 3-protein kinase （PI3K）/protein kinase B （AKT） signaling pathway is involved in the malignant process of tumor cells. The disorder of this pathway can cause a variety of diseases. In recent years，due to the in-depth study of tumor molecular basis，it is found that the activation of this pathway is closely related to the proliferation，invasion，metastasis，apoptosis and angiogenesis of gastric cancer cells. At present，targeting this signal pathway has become a new trend in antitumor research. The research progress of gastric cancer and PI3K/AKT signal pathway is summarized as follows.

Key words: PI3K-AKT signaling pathway, gastric cancer, apoptosis, inhibitor

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