黄芪联合骨髓间充质干细胞治疗阿尔茨海默病的新思路

doi:10.3969/j.issn.2095-1396.2016.02.006

摘要/Abstract

摘要： 阿尔茨海默病（Alzheimer’s disease，AD）是一种进行性认知功能障碍和记忆损害为特征的原发性中枢神经系统退行性疾病。随着社会人口老龄化的不断加深，严重影响老年人生活质量的AD 备受社会关注。目前治疗主要为药物治疗，但其只局限于控制症状及延缓病情。细胞代替疗法在临床的成功应用，使得细胞移植研究成为热点。骨髓间充质干细胞（bone marrow mesenchymal stem cells，BMSCs）具有多向分化的潜能，可以体外诱导分化为神经细胞。将BMSCs 用于AD 的治疗为治疗神经退行性疾病提供了新的思路和方法。黄芪是我国临床常用的传统中药之一，近期研究表明，黄芪治疗AD 有良好的效果，黄芪可以在体外诱导BMSCs 分化成为神经细胞，而黄芪体内诱导BMSCs 治疗AD 的方法国内外未见报道。该文就AD 的研究现状、BMSCs治疗AD 以及黄芪治疗AD 的研究现状做一系统的综述。

关键词: 阿尔茨海默症, 骨髓间充质干细胞, 细胞移植, 黄芪, 诱导分化

Abstract: Alzheimer’s disease （AD） is a primary central nervous system degenerative disease characterized by progressive cognitive impairment and memory impairment. With the aging of the population deepening，serious affection on the quality of life of the elderly AD has been social concern. The current treatment is mainly for drug，but it is only limited to control symptoms and delay the disease. The successful application of cell replacement therapy in clinical makes the research of cell transplantation become a hot spot. Bone marrow mesenchymal stem cells （BMSCs） have the potential of multi-directional differentiation and can be induced to differentiate into neurons in vitro. The use of BMSCs for the treatment of AD has provided new ideas and methods for the treatment of neurodegenerative diseases. Astragalus is one of the traditional Chinese medicine，which commonly used in clinical practice，recent research shows that astragalus is effective for the treatment of AD，and Astragalus can induce BMSCs to differentiate into neurons in vitro，and the treatment of AD by BMSCs induced by Astragalus in vivo has not been reported at home and abroad. In this paper，a systematic review of the research status on the treatment of AD by Astragalus combined with BMSCs，BMSCs treatment of AD and Astragalus treatment of AD will be presented.

Key words: Alzheimer&, rsquo, s disease, bone marrow mesenchymal stem cells, cell transplantation, astragalus, induced differentiation

中图分类号:

R964

李鹏涛, 杨晓楠, 霍艳丽, 张辉. 黄芪联合骨髓间充质干细胞治疗阿尔茨海默病的新思路[J]. 神经药理学报, 2016, 6(2): 31-36.

LI Peng-tao, YANG Xiao-nan, HUO Yan-li, ZHANG Hui. New Ideas of Astragalus Combined with Bone Marrow Mesenchymal Stem Cells in the Treatment of Alzheimer’s Disease[J]. ACTA NEUROPHARMACOLOGICA, 2016, 6(2): 31-36.

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