神经药理学报 ›› 2016, Vol. 6 ›› Issue (2): 26-30.DOI: 10.3969/j.issn.2095-1396.2016.02.005

• 专题论著 • 上一篇    下一篇

四氢孕酮:抑郁和焦虑障碍治疗的潜在新靶点

蒋湘云,尚超,李雷,孙树峥,李云峰,王恒林   

  1. 1. 河北北方学院研究生部,张家口,075000,中国
    2. 北京解放军第309 医院麻醉科,北京,100091,中国
    3. 军事医学科学院毒物药物研究所,北京,100850,中国
  • 出版日期:2016-04-26 发布日期:2016-05-10
  • 通讯作者: 李云峰,男,研究员;Tel:+86-010-66931619,E-mail:lyf619@aliyun.com 王恒林,男,副主任医师;E-mail:hlin309@sina.com
  • 作者简介:蒋湘云,女,硕士研究生;研究方向:麻醉药理学;E-mail:15711293180@163.com 尚超,男,硕士研究生;研究方向:精神药理学;E-mail:shangchao1290@163.com
  • 基金资助:

    国家自然科学基金项目(No.81173036、No.81001635、No.30973516),全军医学科技十二五面上项目(No.CWS12J084)

Allopregnanolone as a New Therapeutic Target for Depression and Anxiety

JIANG Xiang-yun,SHANG Chao,LI Lei,SUN Shu-zheng,LI Yun-feng,WANG Heng-lin   

  1. 1. Department of Postgraduate,Hebei North University,Zhangjiakou,075000,China
    2. Department of Anesthesiology,Hospital 309 of Chinese People’s Liberation Army,Beijing,100091,China
    3. Institute of Pharmacology and Toxicology,Academy of Military Medical Sciences,Beijing,100850,China
  • Online:2016-04-26 Published:2016-05-10
  • Contact: 李云峰,男,研究员;Tel:+86-010-66931619,E-mail:lyf619@aliyun.com 王恒林,男,副主任医师;E-mail:hlin309@sina.com
  • About author:蒋湘云,女,硕士研究生;研究方向:麻醉药理学;E-mail:15711293180@163.com 尚超,男,硕士研究生;研究方向:精神药理学;E-mail:shangchao1290@163.com
  • Supported by:

    国家自然科学基金项目(No.81173036、No.81001635、No.30973516),全军医学科技十二五面上项目(No.CWS12J084)

摘要: 四氢孕酮(allopregnanolone)是18 kDa 转位蛋白(the translocator protein,TSPO)介导胆固醇从线粒体外膜转运至内膜,继而经过一系列酶促反应后生成的神经类固醇。近年来的研究表明,以四氢孕酮为代表的神经类固醇含量下降参与了焦虑和抑郁等多种精神障碍性疾病的发生发展过程,且外源性给予四氢孕酮能够显著改善焦虑抑郁症状。四氢孕酮抗焦虑与抗抑郁的机制目前认为主要与四氢孕酮正向调节γ- 氨基丁酸A(γ-aminobutyric acid A,GABAA)受体有关。此外,四氢孕酮还能调节下丘脑- 垂体- 肾上腺(hypothalamushypophysis-adrenal,HPA)轴的兴奋性,促进神经再生,产生神经保护作用。该综述将就四氢孕酮的产生,在焦虑及抑郁症中的作用及其可能机制进行阐述。

关键词: 四氢孕酮, 焦虑, 抑郁, &, gamma, - 氨基丁酸A 受体, 下丘脑- 垂体- 肾上腺轴, 神经再生

Abstract: Allopregnanolone-the neurosteroid is synthetized from cholesterol via TSPO mediated transfer from outer mitochondrial membrane to inner mitochondrial membrane. Recent study showed reduced level of neurosteroids represented by allopregnanolone were involved in the occurrence and development process of many mental disorders including anxiety and depression. Moreover,exogenous allopregnanolone treatment can significantly improve the anxious and depressive symptoms. The mechanisims underlying the antidepressant and anxiolytic effects of allopregnanolone were considered mainly to be associated with its positive activation on GABAA receptor. In addition,allopregnanolone played an important role in regulating functions of HPA axis as well as stimulating neurogenesis. This review described the production process of allopregnanalone,its role in anxiety and depression and its possible mechanisms of treatment effects.

Key words: allopregnanolone, anxiety, depression, &, gamma, -aminobutyric acid A receptor, hypothalamus-hypophysis-adrenal axis, nerve regeneration

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