神经药理学报 ›› 2020, Vol. 10 ›› Issue (3): 1-7.DOI: 10.3969/j.issn.2095-1396.2020.03.001

• 研究论文 •    下一篇

生物节律紊乱与阿尔茨海默症关联基因的生物信息学挖掘

张浩婷,宋桂芹,崔若彤,郝敏,王文栋   

  1. 河北北方学院医学检验学院,张家口,75000,中国
  • 出版日期:2020-06-26 发布日期:2021-05-14
  • 通讯作者: 王文栋,硕士研究生,讲师;研究方向:生物信息学、代谢与生物钟紊乱;E-mail:190594526@qq.com
  • 作者简介:张浩婷,河北北方学院医学检验学院生物信息学;崔若彤,河北北方学院医学检验学院生物信息学
  • 基金资助:
    河北省高等学校科学技术研究项目(No.Z018032);河北省卫生计生委医学科学研究课题计划项目(No.20180811);河北省高
    等学校科学技术研究重点项目(No.ZD2018076);河北北方学院创新人才培育项目(No.CXRC1316);国家级大学生创新创业
    计划项目(No.201910092006);河北北方学院大学生创新创业训练计划项目(No.xj201945)

Mining Target Genes of Alzheimer’s Disease Associated with Biological Clock by Bioinformatics Analysis

ZHANG Hao-ting,SONG Gui-qin,CUI Ruo-tong,HAO Min,WANG Wen-dong   

  1. College of Lab Medicine,Hebei North University,Zhangjiakou,075000,China
  • Online:2020-06-26 Published:2021-05-14
  • Contact: 王文栋,硕士研究生,讲师;研究方向:生物信息学、代谢与生物钟紊乱;E-mail:190594526@qq.com
  • About author:张浩婷,河北北方学院医学检验学院生物信息学;崔若彤,河北北方学院医学检验学院生物信息学
  • Supported by:
    河北省高等学校科学技术研究项目(No.Z018032);河北省卫生计生委医学科学研究课题计划项目(No.20180811);河北省高
    等学校科学技术研究重点项目(No.ZD2018076);河北北方学院创新人才培育项目(No.CXRC1316);国家级大学生创新创业
    计划项目(No.201910092006);河北北方学院大学生创新创业训练计划项目(No.xj201945)

摘要:

目的:挖掘阿尔茨海默症与生物节律紊乱相关联的治疗性分子靶标。方法:从基因表达综合数据库GEO 中获取GSE28146 芯片数据,使用R 软件挖掘、筛选差异表达基因;利用文本挖掘和蛋白互作筛选出与生物节律紊乱相关联的阿尔茨海默症基因,并对其进行染色体定位、功能注释和通路分析。结果:挖掘出372 个阿尔茨海默症差异表达基因,在染色体上分布广泛,参与转录调控和免疫应答等过程;TIPIN 基因既属于阿尔茨海默症差异表达基因又属于生物节律紊乱基因;有34 个阿尔茨海默症差异表达基因与43 个生物节律基因发生互作。结论:生物节律紊乱与阿尔茨海默症的发生密切相关。

关键词: 阿尔茨海默症, 生物钟基因, 互作分析, 染色体定位, 基因本体论

Abstract:

Objective:To explore the therapeutic molecular targets associated with Alzheimer’s disease and biological rhythm disorders. Methods:The GSE28146 dataset was obtained from the GEO database,and R software was used to mine and screen differentially expressed genes. Alzheimer’s disease genes associated with biological rhythm disorder were screened by text mining
and protein interaction,and the chromosome location,functional annotation and pathway analysis were carried out. Results:A total of 372 differentially expressed genes of Alzheimer’s disease were found,which were widely distributed on chromosomes and participated in the process of transcriptional regulation and immune response;TIPIN gene is the intersection of circadian disorder and Alzheimer’s disease;there are 34 Alzheimer’s disease differential expression genes interacted with 43 biological rhythm genes. Conclusion:Biological rhythm disorder is closely related to the occurrence of Alzheimer’s disease.

Key words: Alzheimer’s disease;biological clock gene;interaction analysis;chromosome , location;gene ontology

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