缺血后适应脑保护机制的研究进展

摘要/Abstract

摘要： 如今延长溶栓时间窗、减轻再灌注损伤是缺血性脑血管病亟待解决的的问题，缺血后适应提供了一种可能的解决方法，故成为研究的热点。缺血后适应通常指的是在组织缺血/再灌注之后进行的一系列短暂血管闭塞/血管再灌注，诱导组织针对缺血/再灌注损伤产生内源性保护作用，减少组织器官缺血再灌注损伤。该文将综述缺血后适应脑保护的基本机制：减少缺血再灌注后脑血流的改变，减少氧化应激产物的产生，抗炎，相关信号传导通路改变。

关键词: 缺血后适应, 缺血再灌注损伤, 脑保护

Abstract: Extending the thrombolysis time window and reducing reperfusion injury are problems urgently needed to be solved in ischemic cerebrovascular disease. Ischemic postconditioning provides a possible solution, which has been becoming a hot research topic. Postconditioning, which refers to a series of brief occlusions and reperfusions of the blood vessels, is conducted after ischemia/reperfusion. Postconditioning can induce organ's endogenous protective effects against ischemia reperfusion injury. This article will discuss the neuroprotective mechanism of ischemic postconditioning: reduction of brain blood flow changes after ischemia reperfusion, attenuation of ROS production and apoptosis, anti-inflammatory, and changes in pathways involved in neuronal death after stroke.

Key words: ischemic postconditioning, ischemina-reperfusion injury, neuroprotection

中图分类号:

R543

蒲举, 姚声涛. 缺血后适应脑保护机制的研究进展[J]. 神经药理学报, 2013, 3(4): 29-34.

PU Ju, YAO Sheng-tao. Research Progress of the Neroprotective Mechanism of Ischemic Postconditionining[J]. ACTA NEUROPHARMACOLOGICA, 2013, 3(4): 29-34.

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