诱发溃疡性结肠炎动物模型化学方法及评价

摘要/Abstract

摘要： 溃疡性结肠炎（ulcerative colitis，UC）又称慢性非特异性溃疡性结肠炎，流行病学资料提示溃疡性结肠炎的发病率在国内外都有逐年增高的趋势，溃疡性结肠炎的研究越来越受到国际肠病学家的关注，所以建立接近于人类的稳定的溃疡性结肠炎动物模型现在看来尤为关键。本文通过对近几年常用的诱发溃疡性结肠炎动物模型化学方法的详述及评价，为基础与临床研究应用提供更多的选择。

关键词: 溃疡性结肠炎, 动物模型, 制备方法, 评价

Abstract: Ulcerative colitis (UC) is also known as chronic nonspecific ulcerative colitis. Epidemiological data suggest that the incidence of ulcerative colitis both in domestic and abroad has increased annually, thus attracting increasing research attention. Establishing valid animal models of ulcerative colitis seems particularly critical. In this review, animal models of ulcerative colitis were reviewed in the hope to provide guidance for related basic and clinical research.

Key words: ulcerative colitis, animal models, preparation methods, evaluation

中图分类号:

R574.62

王倩, 田慧, 张力. 诱发溃疡性结肠炎动物模型化学方法及评价[J]. 神经药理学报, 2013, 3(4): 23-28.

WANG Qian, TIAN Hui, ZHANG Li. Animal Models of Ulcerative Colitis: a Review[J]. ACTA NEUROPHARMACOLOGICA, 2013, 3(4): 23-28.

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