成年海马神经元再生与抑郁症的机制研究进展

神经药理学报 ›› 2013, Vol. 3 ›› Issue (2): 58-64.

• 综述 • 上一篇

成年海马神经元再生与抑郁症的机制研究进展

金灿, 张丹参, 陈乃宏

1. 河北医科大学，石家庄，050017，中国
2. 中国医学科学院，药物研究所 & 神经科学中心，北京，100050，中国
3. 河北科技大学，石家庄，050018，中国
4. 湖南中医药大学，长沙 410208，中国

出版日期:2013-04-26 发布日期:2014-06-27
通讯作者: 张丹参，女，教授，博士生导师；研究方向：神经药理学；Tel: Tel:+86-0311-81668016, E-mail: zhangds2011@126.com
作者简介:金灿，女，博士研究生；研究方向：神经药理学；E-mail: cking5168@163.com
基金资助:
国家自然科学基金项目（No. 81274122、No. 81173578、No. 81202507、No. 81373998、No. U1402221），教育部博士点基金重点项目（No. 20121106130001），北京市自然科学基金项目（No. 7131013、No. 7142115），新药作用机制研究与药效评价北京市重点实验室资助项目（No. BZ0150），中央级公益性科研院所基本科研业务费专项资金（No. 2014RC03）

Research Advance in Relationship between Adult Hippocampal Neurogenesis and Mechanisms of Depression

Jin Can, ZHANG Dan-shen, CHEN Nai-hong

1. Hebei Medical University，Shijiazhuang，050017，China
2. Institute of Materia Medica & Neuroscience Center, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
3. Hebei University of Science and Technology, Shijiazhuang, 050018, China
4. Hunan University of Chinese Medicine, Changsha, 410208, China

Online:2013-04-26 Published:2014-06-27
Contact: 张丹参，女，教授，博士生导师；研究方向：神经药理学；Tel: Tel:+86-0311-81668016, E-mail: zhangds2011@126.com
About author:金灿，女，博士研究生；研究方向：神经药理学；E-mail: cking5168@163.com
Supported by:
国家自然科学基金项目（No. 81274122、No. 81173578、No. 81202507、No. 81373998、No. U1402221），教育部博士点基金重点项目（No. 20121106130001），北京市自然科学基金项目（No. 7131013、No. 7142115），新药作用机制研究与药效评价北京市重点实验室资助项目（No. BZ0150），中央级公益性科研院所基本科研业务费专项资金（No. 2014RC03）

摘要/Abstract

摘要： 成年海马脑区有持续神经再生，早期研究表明抑郁模型的成年神经再生受损，文中将从抑郁患者海马影像学改变、海马神经再生与抑郁的关系及抗抑郁药物对神经再生的影响几个方面，对抑郁症与成年海马神经再生的研究现状进行概括分析。

关键词: 抑郁, 海马, 神经再生, 齿状回

Abstract: Adult hippocampal has continuous neurogenesis, early studies have found that adult neurogenesis is impaired in models of depression. In this review, we will analyze the current studies on the relationship between depression and adult hippocampal neurogenesis as follows: image changes in depression patients, relationship between hippocampal neurogenesis and depression, and antidepressant effects on neurogenesis.

Key words: depression, hippocampal, neurogenesis, dentate gyrus

金灿, 张丹参, 陈乃宏. 成年海马神经元再生与抑郁症的机制研究进展[J]. 神经药理学报, 2013, 3(2): 58-64.

Jin Can, ZHANG Dan-shen, CHEN Nai-hong. Research Advance in Relationship between Adult Hippocampal Neurogenesis and Mechanisms of Depression[J]. Acta Neuropharmacologica, 2013, 3(2): 58-64.

参考文献

[1] Alize J Ferrari, Fiona J Charlson, Rosana E Norman. et al. Burden of depressive disorders by country, sex, age, and year: findings from the global burden of disease study 2010 [J]. PLoS Med, 2013, 10(11): e1001547.

[2] Samantha G Block, Charles B Nemeroff. Emerging antidepressants to treat major depressive disorder [J]. Asian J Psychiatr, 2014, 12:7-16.

[3] Djoher Nora Abrous, Muriel Koehl, Michel Le Moal. Adult neurogenesis: from precursors to network and physiology [J]. Physiol Rev, 2005, 85(2): 523-569.

[4] Joseph Altman, Das Gopal D. Autoradiographic and histological evidence of postnatal hippocampal neurogenesis in rats [J] J Comp Neurol, 1965, 124(3): 319-335.

[5] Peter S Eriksson, Ekaterina Perfilieva, Thomas Björk-Eriksson, et al. Neurogenesis in the adult human hippocampus [J]. Nature Medicine, 1998, 4(11): 1313-1317.

[6] Ge Shaoyu, Chih-hao Yang, Kuei-sen Hsu, et al. A critical period for enhanced synaptic plasticity in newly generated neurons of the adult brain [J]. Neuron, 2007, 54(4): 559-566.

[7] Itaru Imayoshi, Masayuki Sakamoto, Toshiyuki Ohtsuka T, et al. Roles of continuous neurogenesis in the structural and functional integrity of the adult forebrain[J]. Nat Neurosci, 2008, 11(10): 1153-1161.

[8] Toshiaki Nakashiba, Jesse D Cushman, Kenneth A Pelkey, et al. Young dentate granule cells mediate pattern separation, whereas old granule cells facilitate pattern completion [J]. Cell, 2012, 149(1): 188-201.

[9] Stockmeier C A, Mahajan G J, Konick L C, et al. Cellular changes in the postmortem hippocampus in major depression [J]. Biol Psychiatry, 2004, 56(9): 640-650.

[10] Yun-Hee Sung, Mal-Soon Shin, Sehyung Cho, et al. Depression-like state in maternal rats induced by repeated separation of pups is accompanied by a decrease of cell proliferation and an increase of apoptosis in the hippocampus[J]. Neurosci Lett, 2010, 470(1): 86-90.

[11] Margaret C McKinnon, Kaan Yucel, Anthony Nazarov, et al. A meta-analysis examining clinical predictors of hippocampal volume in patients with major depressive disorder [J]. J Psychiatry Neurosci, 2009, 34(1): 41-54.

[12] Reif A, Fritzen S, Finger M, et al. Neural stem cell proliferation is decreased in schizophrenia, but not in depression[J]. Mol Psychiatry, 2006, 11(5): 514-522.

[13] Maura Boldrini, Mark D Underwood, Hen Rene, et al. Antidepressants increase neural progenitor cells in the human hippocampus[J]. Neuropsychopharmacology, 2009, 34(11): 2376-2389.

[14] Lucassen P J, Stumpel M W, Wang Q, et al. Decreased numbers of progenitor cells but no response to antidepressant drugs in the hippocampus of elderly depressed patients [J]. Neuropharmacology, 2010, 58(6): 940-949.

[15] Huang Yu-shan, Nicholas J Coupland, R Marc Lebel, et al. Structural changes in hippocampal subfields in major depressive disorder: a high-field magnetic resonance imaging study [J]. Biol Psychiatry, 2013, 74(1): 62-68.

[16] Jacobs B L, Henriette Van Praag, Gage F H. et al. Adult brain neurogenesis and psychiatry: a novel theory of depression [J]. Mol Psychiatry, 2000, 5(3): 262-269.

[17] Kara Pham, Juan Nacher, Patrick R Hof, et al. Repeated restraint stress suppresses neurogenesis and induces biphasic PSA-NCAM expression in the adult rat dentate gyrus [J]. Eur J Neurosci, 2003, 17(4): 879-886.

[18] Alex Dranovsky, Alyssa M Picchini, Tiffany Moadel, et al. Experience dictates stem cell fate in the adult hippocampus [J]. Neuron, 2011, 70(5): 908-923.

[19] P Van Bokhoven, Oomen C A, Hoogendijk W J, et al. Reduction in hippocampal neurogenesis after social defeat is long-lasting and responsive to late antidepressant treatment [J]. Eur J Neurosci, 2011, 33(10): 1833-1840.

[20] Kuem-Ju Lee, Sung-Jin Kim, Suk-Won Kim, et al. Chronic mild stress decreases survival, but not proliferation, of new-born cells in adult rat hippocampus [J]. Exp Mol Med, 2006, 38(1): 44-54.

[21] Cameron H A, Gould E. Adult neurogenesis is regulated by adrenal steroids in the dentate gyrus [J]. Neuroscience, 1994, 61(2): 203-209.

[22] Nicola D Hanson, Michael J Owens, Katherine A Boss-Williams , et al. Several stressors fail to reduce adult hippocampal neurogenesis [J]. Psychoneuroendocrinology, 2011, 36(10): 1520-1529.

[23] Tarique D Perera, Andrew J Dwork, Kathryn A Keegan, et al. Necessity of hippocampal neurogenesis for the therapeutic action of antidepressants in adult nonhuman primates [J]. PLoS One, 2011, 6(4): e17600.

[24] Elizabeth Gould, Patima Tanapat, Bruce S McEwen, et al. Proliferation of granule cell precursors in the dentate gyrus of adult monkeys is diminished by stress [J]. Proc Natl Acad Sci USA, 1998, 95(6): 3168-3171.

[25] Melody V Wu, Jul Lea Shamy, Gillinder Bedi, et al. Impact of social status and antidepressant treatment on neurogenesis in the baboon hippocampus [J]. Neuropsychopharmacology, 2014, 39(8): 1861-1871.

[26] Newfei Ho, Jacob M Hooker, Sahay A, et al. In vivo imaging of adult human hippocampal neurogenesis: progress, pitfalls and promise [J]. Mol Psychiatry, 2013, 18(4): 404-416.

[27] Louis N Manganas, Zhang Xue-ying, Li Yao, et al. Magnetic resonance spectroscopy identifies neural progenitor cells in the live human brain [J]. Science, 2007, 318(5852): 980-985.

[28] Pereira A C, Huddleston D E, Brickman A M, et al. An in vivo correlate of exercise-induced neurogenesis in the adult dentate gyrus [J]. Proc Natl Acad Sci USA, 2007, 104(13): 5638-5643.

[29] Cameron H A, Gould E. Adult neurogenesis is regulated by adrenal steroids in the dentate gyrus [J]. Neuroscience, 1994, 61(2): 203-209..

[30] Elizabeth Gould, Heather A Cameron, Deborah C Daniels, et al. Adrenal hormones suppress cell division in the adult rat dentate gyrus [J]. J Neurosci, 1992, 12(9): 3642-3650.

[31] Jason S Snyder, Amelie Soumier, Michelle Brewer, et al. Adult hippocampal neurogenesis buffers stress responses and depressive behavior [J]. Nature, 2011, 476(7361): 458-461.

[32] Revest J M, Dupret D, KoehI M, et al. Adult hippocampal neurogenesis is involved in anxiety-related behaviors [J]. Mol Psychiatry, 2009, 14(10): 959-967.

[33] Simon M G Braun, Sebastian Jessberger. Adult neurogenesis and its role in neuropsychiatric disease, brain repair and normal brain function [J]. Neuropathol Appl Neurobiol, 2014, 40(1): 3-12.

[34] Arnaud Tanti, Catherine Belzung. Hippocampal neurogenesis: a biomarker for depression or antidepressant effects? Methodological considerations and perspectives for future research [J]. Cell Tissue Res, 2013, 354(1): 203-219.

[35] Gisele Pereira Dias, Ronan Hollywood, Mario Cesar Bevilaqua, et al. Consequences of cancer treatments on adult hippocampal neurogenesis: implications for cognitive function and depressive symptoms [J]. Neuro Oncol, 2014, 16(4): 476-492.

[36] William M Lydiatt, Diane Bessette, Kendra K Schmid, et al. Prevention of depression with escitalopram in patients undergoing treatment for head and neck cancer: randomized, double-blind, placebo-controlled clinical trial [J]. JAMA Otolaryngol Head Neck Surg, 2013, 139(7): 678-686.

[37] Jessica E Malberg, Amelia J Eisch, Eric J Nestler, et al. Chronic antidepressant treatment increases neurogenesis in adult rat hippocampus [J]. J Neurosci, 2000, 20(24): 9104-9110.

[38] Torsen M Madsen, Alexandra Treschow, Johan Benqzon, et al. Increased neurogenesis in a model of electroconvulsive therapy [J]. Biol Psychiatry, 2000, 47(12): 1043-1049.

[39] Brian W Scott, J Martin Wojtowicz, W Mclntyre Burnham. Neurogenesis in the dentate gyrus of the rat following electroconvulsive shock seizures [J]. Exp Neurol, 2000, 165(2): 231-236.

[40] Chen Guang, Grazyna Rajkowska, Du Fu, et al. Enhancement of hippocampal neurogenesis by lithium [J]. J. Neurochem, 2000, 75(4): 1729-1734.

[41] Kerri A Holick, Daniel C Lee, Rene Hen, et al. Behavioral effects of chronic fluoxetine in BALB/cJ mice do not require adult hippocampal neurogenesis or the serotonin 1A receptor [J]. Neuropsychopharmacology, 2008, 33(2): 406-417.

[42] Daniel S Cowen, Luiz F Takase, Casimir A Fornal, et al. Age-dependent decline in hippocampal neurogenesis is not altered by chronic treatment with fluoxetine [J]. Brain Res, 2008, 1228: 14-19.

[43] Maura Boldrini, Adrienne N Santiago, Rene Hen, et al. Hippocampal granule neuron number and dentate gyrus volume in antidepressant-treated and untreated major depression [J]. Neuropsychopharmacology, 2013, 38(6): 1068-1077.

[44] Maura Boldrini, Tanya H Butt, Adrienne N Santiago, et al. Benzodiazepines and the potential trophic effect of antidepressants on dentate gyrus cells in mood disorders [J]. Int J Neuropsychopharmacol, 2014, 17(12): 1923-1933.

[45] Arnone D, Mckie S, Elliott R, et al. State-dependent changes in hippocampal grey matter in depression [J]. Mol Psychiatry, 2013, 18(12): 1265-1272.

[46] Indira Tendolkar, Marleen Van Beek, Iris van Oostrom, et al. Electroconvulsive therapy increases hippocampal and amygdala volume in therapy refractory depression: a longitudinal pilot study [J]. Psychiatry Res, 2013, 214(3): 197-203.

[47] Eric Vermetten, Meena Vythilinqam, Steven M Southwick, et al. Long-term treatment with paroxetine increases verbal declarative memory and hippocampal volume in posttraumatic stress disorder [J]. Biol Psychiatry, 2003, 54(7): 693-702.

[48] Ronald S Duman. Neural plasticity: consequences of stress and actions of antidepressant treatment [J]. Dialogues Clin Neurosci, 2004, 6(2): 157-169.

[49] Huang G J, Bannerman D, Flint J. Chronic fluoxetine treatment alters behavior, but not adult hippocampal neurogenesis, in BALB/cJ mice [J]. Mol Psychiatry, 2008, 13(2): 119-121.

[50] Benjamin H Singer, Emily M Jutkiewicz, Cynthia L Fuller, et al. Conditional ablation and recovery of forebrain neurogenesis in the mouse [J]. J Comp Neurol, 2009, 514(6): 567-582.

[51] David D J, Samuels B A, Rainer Q, et al. Neurogenesis-dependent and -independent effects of fluoxetine in an animal model of anxiety/depression [J]. Neuron, 2009, 62(4): 479-493.

[52] Surget A, Tanti A, Leonardo E D, et al. Antidepressants recruit new neurons to improve stress response regulation [J]. Mol Psychiatry, 2011, 16(12): 1177-1188.

[53] Karl Deisseroth. Circuit dynamics of adaptive and maladaptive behavior [J]. Nature, 2014, 505(7483): 309-317.

[54] Byung Kook Lim, Kee Wui Huang, Brad A Grueter, et al. Anhedonia requires MC4R-mediated synaptic adaptations in nucleus accumbens [J]. Nature, 2012, 487(7406): 183-189.

[55] Amar Sahay, Kimberly N Scobie, Alexis S Hill, et al. Increasing adult hippocampal neurogenesis is sufficient to improve pattern separation [J]. Nature, 2011, 472(7344): 466-470.

[56] Andrew A Pieper, Xie Shan-hai, Emanuela Capota, et al. Discovery of a proneurogenic, neuroprotective chemical[J]. Cell, 2010, 142(1): 39-51.

[57] Walker A K, Rivera P D, Wang Q, et al. The P7C3 class of neuroprotective compounds exerts antidepressant efficacy in mice by increasing hippocampal neurogenesis [J]. Mol Psychiatry, 2014, 20(4):500-508.

成年海马神经元再生与抑郁症的机制研究进展

Research Advance in Relationship between Adult Hippocampal Neurogenesis and Mechanisms of Depression

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