神经药理学报 ›› 2013, Vol. 3 ›› Issue (2): 49-57.
Luo Yi, Chen Jian-guo, Wang Fang
出版日期:2013-04-26
发布日期:2014-06-27
通讯作者:
Dr. Wang Fang，Female, Born in 1975，Professor， Doctoral tutor；Research direction：Neuropsychopharmacology；Fax: +86 27 83692608；Tel: +86 27 83692636； E-mail addresses： wangfangtj0322@163.com
作者简介:Luo Yi，Male，PhD student； Research direction：Neuroscience；E-mail:luoyitj@126.com
基金资助:National Basic Research Program of China (the 973 Program, No. 2013CB531303 to Dr. J.G.C.; No. 2014CB744601 to F.W.) and the National Natural Scientific Foundation of China (NSFC, No. 81222048 to F.W.). It was also supported by the International Science & Technology Cooperation Program of China (No. 2011DFA32670 to J.G.C.) and PCSIRT (No. IRT13016).
Luo Yi, Chen Jian-guo, Wang Fang
Online:2013-04-26
Published:2014-06-27
Contact:
Dr. Wang Fang，Female, Born in 1975，Professor， Doctoral tutor；Research direction：Neuropsychopharmacology；Fax: +86 27 83692608；Tel: +86 27 83692636； E-mail addresses： wangfangtj0322@163.com
About author:Luo Yi，Male，PhD student； Research direction：Neuroscience；E-mail:luoyitj@126.com
Supported by:National Basic Research Program of China (the 973 Program, No. 2013CB531303 to Dr. J.G.C.; No. 2014CB744601 to F.W.) and the National Natural Scientific Foundation of China (NSFC, No. 81222048 to F.W.). It was also supported by the International Science & Technology Cooperation Program of China (No. 2011DFA32670 to J.G.C.) and PCSIRT (No. IRT13016).
摘要： 在经历过创伤性事件的人群中，常常会出现创伤后应激综合症以及重度抑郁症并发的现象。但是创伤后应激综合症后易发重度抑郁症的细胞分子机制还未见报道。在这篇综述中，我们从突触可塑性的角度，将创伤后应激综合症以及重度抑郁症中下丘脑-垂体-肾上腺素轴、皮质醇、炎症因子以及神经营养因子等指标的改变进行了比较。这些研究结果提示神经营养因子、尤其是脑源性的神经营养因子极有可能是联系创伤后应激综合症以及重度抑郁症的关键因子。后续的研究应该侧重于脑源性的神经营养因子在创伤后应激综合症后易发抑郁症的作用机制中。调控脑源性神经营养因子的药物将可以用来预防创伤后应激综合症后重度抑郁症的发生。
Luo Yi, Chen Jian-guo, Wang Fang. Brain-Derived Neurotrophic Factor: a Link between Posttraumatic Stress Disorder and Major Depressive Disorder[J]. 神经药理学报, 2013, 3(2): 49-57.
Luo Yi, Chen Jian-guo, Wang Fang. Brain-Derived Neurotrophic Factor: a Link between Posttraumatic Stress Disorder and Major Depressive Disorder[J]. ACTA NEUROPHARMACOLOGICA, 2013, 3(2): 49-57.
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