神经药理学报

神经药理学报 ›› 2025, Vol. 15 ›› Issue (4): 8-.DOI: 10.3969/j.issn.2095-1396.2025.04.002

• 综述 • 上一篇    下一篇

溃疡性结肠炎动物模型及评价指标

马琳，范荣珍，李炜，张丹参   

  1. 1. 河北科技大学化学与制药工程学院，石家庄，050018，中国 

    2. 河北北方学院药学院，张家口，075000，中国

  • 出版日期:2025-08-26 发布日期:2025-10-15
  • 通讯作者: 张丹参，教授，博士生导师；研究方向：神经药理学；E-mail: zhangds2011@126.com
  • 作者简介:马琳，硕士研究生；研究方向：药理学；E-mail: 2273501313@qq.com

Animal Models of Ulcerative Colitis and Evaluation Indicators

MA Lin, FAN Rong-zhen, LI Wei, ZHANG Dan-shen   

  1. 1. College of Chemical and Pharmaceutical Engineering, Hebei University of Science and Technology, Shijiazhuang, 050018, China 

    2. School of Pharmacy, Hebei North University, Zhangjiakou, 075000, China

  • Online:2025-08-26 Published:2025-10-15

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摘要：

溃疡性结肠炎(ulcerative colitis, UC) 是一种慢性非特异性肠道疾病，病变累及直肠和结肠，临床表现为 腹痛、腹泻、黏液脓血便等。近年来，UC 发病率激增，严重影响了患者生活质量。溃疡性结肠炎的发病机制复杂 多样，涉及环境因素、遗传因素、机体免疫及心理因素等。为深入探究该疾病的致病机理、调控机制以及开发针对 性治疗药物，构建合适的动物实验模型显得尤为重要。该文通过对目前诱发溃疡性结肠炎动物的选择、造模方法、 模型评价指标进行概括，以期为科研实验和临床实践提供更多可行性方案，同时为相关领域的研究人员后续的研 究者提供参考。

关键词: 溃疡性结肠炎, 动物模型, 造模方法, 评价指标

Abstract:

Ulcerative colitis (UC) is a chronic non-specific intestinal disease with lesions involving the rectum and colon, and clinical manifestations include abdominal pain, diarrhea, and muco-purulent and bloody stools. In recent years, the incidence of UC has surged, which seriously affects the quality of life of patients. The pathogenesis of ulcerative colitis is complex and diverse, involving environmental factors, genetic factors, body immunity and psychological factors. In order to deeply investigate the pathogenesis and regulatory mechanism of this disease and develop targeted therapeutic drugs, it is particularly important to construct suitable animal experimental models. In this paper, we summarize the current selection of animals inducing ulcerative colitis, modeling methods, and model evaluation indexes, in order to provide more feasible solutions for scientific research experiments and clinical practice, and at the same time to provide reference for researchers in related fields to follow up the researchers.

Key words: ulcerative colitis, animal model, modeling method, evaluation indicators

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