Ulcerative colitis (UC) is a chronic non-specific intestinal disease with lesions
involving the rectum and colon, and clinical manifestations include abdominal pain, diarrhea, and
muco-purulent and bloody stools. In recent years, the incidence of UC has surged, which seriously
affects the quality of life of patients. The pathogenesis of ulcerative colitis is complex and diverse,
involving environmental factors, genetic factors, body immunity and psychological factors. In
order to deeply investigate the pathogenesis and regulatory mechanism of this disease and develop
targeted therapeutic drugs, it is particularly important to construct suitable animal experimental
models. In this paper, we summarize the current selection of animals inducing ulcerative colitis,
modeling methods, and model evaluation indexes, in order to provide more feasible solutions for
scientific research experiments and clinical practice, and at the same time to provide reference for
researchers in related fields to follow up the researchers.
