Acta Neuropharmacologica

Previous Articles     Next Articles

The Role of Gut Flora in the Pathogenesis of Alzheimer’s Disease

LIU Nuo,WANG Zhen-zhen,CHEN Nai-hong   

  1. Institute of Material Medica & Neuroscience Center,Chinese Academy of Medical Sciences,Beijing,100050,China
  • Online:2017-10-26 Published:2017-12-01
  • Contact: 陈乃宏,男,博士,教授;研究方向:神经药理学;Tel:+86-010-63165177,E-mail:chennh@imm.ac.cn
  • About author:刘诺,男,硕士;研究方向:神经药理学
  • Supported by:
    国家自然科学基金项目(No.81603315、No.81730096、No.U1402221),中国医学科学院医学与健康科技创新工程项目(No.2016-I2M-1-004),神经变性病教育部重点实验室开放研究课题( No.2016SJBX03),国家重点实验室开放课题( No.GTZK201610),中国博士后科学基金( No.2013M540066)

Abstract:

Along with aggravation of aging of population,the incidence of Alzheimer’s disease is getting higher and higher. However,etiological treatment of this disease is still unsatisfying. In recent years,the role of gut flora in the pathogenesis of AD has received more and more attention. Types and ratios of gut flora change along with the growth of the age,and the variety of quantities of metabolites makes a difference in the cognitive behavior. Besides,gut flora interacts with gut-brain axis. Nowadays,we have confirmed the role of gut flora in mechanisms of the pathogenesis of AD,including amyloidosis,hyperphosphorylation of tau protein,neuro-inflammation,oxidative stress damage,increase of the permeability of the bloodbrain barrier neurotransmitter imbalance and insulin resistance. In the future,specific regulation of pathogenesis-related gut bacteria will be an important research area.

Key words: gut flora, Alzheimer’s disease, mechanisms of pathogenesis

CLC Number: