Research Progress in the Mechanisms of Cerebral Ischemia Hypoxia Preconditioning Antagonizing Cerebral Ischemia and Hypoxia Injury

Abstract

Abstract: The phenomenona of ischemia/hypoxia preconditioning were first discovered in heart. Numerous studies，carried out at different levels，have confirmed that there are also preconditioning phenomenona in brain，and the phenomenona of ischemia/hypoxia preconditioning in brain have become a hot topic in the field of ischemia and hypoxia. Cerebral ischemia/hypoxia preconditioning (CIP) can decrease cell apoptosis，increase the anti-oxidant ability and decrease oxidant injury，increase the generation of hypoxic inducible factor-1 and heat shock protein 70 through multiple signal transduction pathways. There are interactions among the mechanisms about CIP which are relatively independent.

Key words: ischemia hypoxia preconditioning, apoptosis, reactive oxygen species, signal transduction, hypoxic inducible factor, heat shock proteins

CLC Number:

R743

YUAN Heng-jie，LOU Jian-shi. Research Progress in the Mechanisms of Cerebral Ischemia Hypoxia Preconditioning Antagonizing Cerebral Ischemia and Hypoxia Injury[J]. Acta Neuropharmacologica, 2011, 1(4): 42-47.

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