Neurotoxic Effects of Metal Oxide Nanomaterials

Abstract

Abstract: Manufactured metal oxide nanomaterials are utilized in a wide variety of applications including in diagnostic devices, cell tracking, drug targeting and regenerative medicine, and their potential adverse effects on both the environment and human health have been concerned. It has been reported that metal oxide nanomaterials-induced reactive oxygen species (ROS) generation and cytokine release play important roles in the blood-brain barrier damage and central nervous system (CNS) dysfunction. However, the mechanism underlying metal oxide nanomaterials-related neurotoxicity has not been fully elucidated. Here, the neurotoxic effects of metal oxide nanoparticles on central nervous system are reviewed.

Key words: metal oxide nanoparticles, nervous system, oxidative stress

WANG1 Jie-ting, ZHANG Fang, DING Wen-jun. Neurotoxic Effects of Metal Oxide Nanomaterials[J]. Acta Neuropharmacologica, 2013, 3(3): 39-47.

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