Prospective Overview of Nerve Growth Factor on the Pharmacotherapy of Ophthalmic Diseases

Abstract

Abstract: Nerve growth factor(NGF) is a neurotrophic factor, which is widely distributed in nervous tissue and peripheral target tissues. In the central nervous system, NGF shows neurotrophic and neurite promoting effects on the neurons, and thereby participates in the process of neuronal differentiation, development and repair. Recent findings demonstrate that retinal ganglion cells (RGC) express various neurotrophins, including NGF, and NGF plays its role through binding to the high affinity NGF tyrosine kinase receptor TrkA or low affinity receptor p75NTR. TrkA exists in retina like RGC, while p75NTR exists in glia cells. This review discussed the expression of NGF and its receptors in ocular tissues, the protective effect of NGF against optic nerve, retinal and corneal damages, and the treatment of NGF in the glaucoma and dry eye syndrome will be discussed as well.

Key words: nerve growth factor, nerve growth factor receptors, ophthalmic diseases

CLC Number:

R962.1

XU Yuan-yuan,XU Jiang-ping. Prospective Overview of Nerve Growth Factor on the Pharmacotherapy of Ophthalmic Diseases[J]. Acta Neuropharmacologica, 2012, 2(4): 40-46.

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