ACTA NEUROPHARMACOLOGICA ›› 2020, Vol. 10 ›› Issue (2): 55-64.DOI: 10.3969/j.issn.2095-1396.2020.02.010

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The Relationship between Hyperuricemia and Chronic Kidney Disease

LIN Si-mei,ZHOU Hong,YANG Bao-xue   

  1. Department of Pharmacology,School of Basic Medical Sciences,Peking University,Beijing,100191,China
  • Online:2020-04-26 Published:2020-04-26
  • Contact: 杨宝学,教授;研究方向:肾脏药理学;E-mail:baoxue@bjmu.edu.cn
  • About author:林思梅,博士研究生;研究方向:肾脏药理学;E-mail:linsimei@pku.edu.cn 周虹,副教授;研究方向:肾脏药理学;E-mail:rainbow_zhou@126.com
  • Supported by:
    国家自然科学基金(No. 81620108029,No. 81974083,No. 81873597)

Abstract:

In China,the prevalence of hyperuricemia (HUA) is over 13% (males as high as 18.5%),and shows the trend of increasing year by year. Hyperuricemia mainly affects the kidney,leading directly to acute/chronic uric acid nephropathy or uric acid stone,and manifests chronic kidney disease (CKD) characterized by chronic interstitial nephritis and renal fibrosis caused by uric acid. CKD is a progressive disease in which the structure and function of kidney are impaired,which has seriously affected human health and living quality. This article reviews the effect of hyperuricemia on the kidney,the correlation between uric acid and CKD,the pathogenesis and the therapeutic strategy.

Key words: uric acid, chronic kidney disease, inflammation, oxidative stress, uric acidlowering therapies