The Progress on Studies of Chloride Channels

Abstract

Abstract: Chloride is the most abundant anion in all organisms. Chloride channel, besides some active transporters, is one of the important pathways which allow chloride to go through the cell membrane. Chloride channels are probably present in every cell, from bacteria to mammals. Their physiological tasks include but not limited to cell volume regulation, stabilization of the membrane potential, signal transduction and transepithelial transporting. This review focus on the physiological functions and molecular identity of calcium activated chloride channels and volume regulated chloride channels, and also review briefly on voltage gated chloride channels, cystic fibrosis transmembrane conductance regulator and ligand gated chloride channels.

Key words: Chloride ion, channel, calcium activated chloride channels(CaCCs), TMEM16A, Bestrophin1, volume regulated chloride channels

LIU Ya-ni, ZHANG Hui-ran, ZHAO Chen, HUANG Dong-yang, DU Yu-wei, ZHANG Hai-lin. The Progress on Studies of Chloride Channels[J]. Acta Neuropharmacologica, 2015, 5(4): 33-42.

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