The Correlation Between Inhalation Anesthesia and Postoperative Cognitive Dysfunction

Abstract

Abstract: Postoperative cognitive dysfunction is recognized as a common surgical procedures complication in older adults especially following the general anesthesia. The first dangerous factor influencing POCD development is aging. Many researches indicated that anesthetic might play an important role during the POCD development. It was reported that type of anesthesia did not affect learning and memory ability，but anesthetic drugs might influence the cognitive function through lots of mechanisms. Isoflurane and sevoflurane，as inhaled anesthesia drugs，have been widely researched. Related studies indicated that effect of inhaled anesthetics on cognitive function was related to the concentration of inhaled anesthesia drug. The high concentrations of inhaled anesthetics drug could decrease the learning and memory function. The low concentrations of inhalation anesthetics drug could ease the beta amylase deposition and promote the learning and memory ability. The mechanism needs further research.

Key words: postoperative cognitive dysfunction, inhalation anesthesia, Isoflurane, Sevoflurane

CLC Number:

R338.64

CAO Gao-ya, WANG Xin-sheng. The Correlation Between Inhalation Anesthesia and Postoperative Cognitive Dysfunction[J]. ACTA NEUROPHARMACOLOGICA, 2015, 5(3): 17-21.

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